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Concept

Resolution (mass spectrometry)

Publications associées (30)

Innovative Biomarkers for Obesity and Type 1 Diabetes Based on Bifidobacterium and Metabolomic Profiling

Stephan Morgenthaler, Paul Refinetti

The role of Bifidobacterium species and microbial metabolites such as short-chain fatty acids (SCFAs) and human milk oligosaccharides in controlling intestinal inflammation and the pathogenesis of obesity and type 1 diabetes (T1D) has been largely studied ...

MDPI2024

New Approach for the Identification of Isobaric and Isomeric Metabolites

Thomas Rizzo, Ahmed Ben Faleh, Stephan Warnke, Ali H Abikhodr

The structural elucidation of metabolite molecules is important in many branches of the life sciences. However, the isomeric and isobaric complexity of metabolites makes their identification extremely challenging, and analytical standards are often require ...

2023

Identification of human milk oligosaccharide positional isomers by combining IMS-CID-IMS and cryogenic IR spectroscopy

Thomas Rizzo, Ahmed Ben Faleh, Stephan Warnke, Vasyl Yatsyna, Ali H Abikhodr

High-resolution ion mobility spectrometry (IMS) coupled with cryogenic infrared spectroscopy has proven to be a powerful technique for the identification of oligosaccharides. However, the need for an extensive database, combined with the scarcity of pure s ...

2023

Advancing Glycan Analysis: Cryogenic Ion Spectroscopy for Database-Driven Identification

Ali H Abikhodr

Glycans play a pivotal role in both physiological processes; however, the field of glycobiology remains relatively understudied within biochemistry. The intricate complexity of glycans, coupled with their abundance of isomeric forms, presents formidable ch ...

EPFL2023

Combining ion mobility spectrometry and cryogenic ion spectroscopy with enzymatic digestion/synthesis for the study of N-linked glycans

Irina Märki

Glycans play an essential role in numerous physiological and pathological processes of living organisms. Despite their significant biological relevance, glycobiology remains one of the least explored fields of biochemistry. The intrinsic isomeric complexit ...

EPFL2023

Oxidative Water Treatment: The Track Ahead

Urs von Gunten

Chemical oxidation has been applied in municipal water treatment for more than a century, initially for disinfection. In the early decades, chlorine disinfection was adopted in the fight against waterborne disease. However, the oxidative properties of chlo ...

2023

Identification of Mobility-Resolved N-Glycan Isomers

Thomas Rizzo, Ahmed Ben Faleh, Stephan Warnke, Priyanka Bansal, Robert Paul Pellegrinelli

Glycan analysis has evolved considerably during the last decade. The advent of high-resolution ion-mobility spectrometry has enabled the separation of isomers with only the slightest of structural differences. However, the ability to separate such species ...

AMER CHEMICAL SOC2022

A New Strategy Coupling Ion-Mobility-Selective CID and Cryogenic IR Spectroscopy to Identify Glycan Anomers

Thomas Rizzo, Ahmed Ben Faleh, Stephan Warnke, Eduardo Carrascosa Casado, Priyanka Bansal, Robert Paul Pellegrinelli, Lei Yue

Determining the primary structure of glycans remains challenging due to their isomeric complexity. While high-resolution ion mobility spectrometry (IMS) has recently allowed distinguishing between many glycan isomers, the arrival-time distributions (ATDs) ...

2022

Standard-Free Quantification of Dicarboxylic Acids: Case Studies with Salt-Rich Effluents and Serum

Christian Ludwig, Daniil Salionov

The present study evaluates the ionization efficiency (IE) of linear and branched C2–C14 dicarboxylic acids (DCAs) by electrospray ionization (ESI) under different conditions. The influence of the concentration of organic modifier (MeOH); mobile phase addi ...

2022

A machine learning approach to correct for mass resolution effects in simulated halo clustering statistics

Cheng Zhao, Daniel Felipe Forero Sanchez

The increase in the observed volume in cosmological surveys imposes various challenges on simulation preparations. First, the volume of the simulations required increases proportionally to the observations. However, large-volume simulations are quickly bec ...

OXFORD UNIV PRESS2022

Unravelling the structures of sodiated beta-cyclodextrin and its fragments

Thomas Rizzo, Eduardo Carrascosa Casado, Robert Paul Pellegrinelli, Ali H Abikhodr

We present cryogenic infrared spectra of sodiated beta-cyclodextrin beta-CD + Na, a common cyclic oligosaccharide, and its main dissociation products upon collision-induced dissociation (CID). We characterize the parent ions using high-resolution ion ...

2021

Identifying Mixtures of Isomeric Human Milk Oligosaccharides by the Decomposition of IR Spectral Fingerprints

Thomas Rizzo, Ahmed Ben Faleh, Stephan Warnke, Vasyl Yatsyna, Ali H Abikhodr

The analysis of glycans presents a significant challenge that arises from their isomeric heterogeneity. While high-resolution ion mobility spectrometry (IMS) has shown the ability to resolve subtly different glycan isomers, their unambiguous assignment rem ...

2021

A gas phase approach for glycan analysis: Combining ultrahigh-resolution ion mobility spectrometry with cryogenic vibrational spectroscopy

Ahmed Ben Faleh

The last decades have been punctuated by the development of revolutionary analytical technologies that have enabled the analysis of biomolecular structures and unraveled the roles they play in biological systems. However, certain classes of biomolecules re ...

EPFL2021

Analyzing glycans cleaved from a biotherapeutic protein using a combination of ion mobility spectrometry and cryogenic ion spectroscopy

Natalia Yalovenko

The characterization of biomolecules plays a central role in biomedical research. The development of state-of-the-art technologies is needed to make such analyses faster, more sensitive, and more accurate. While mass spectrometry continues to play a centra ...

EPFL2021

Accelerating photofragmentation UV Spectroscopy–Mass spectrometry fingerprinting for quantification of isomeric peptides

Oleg Boyarkine, Erik Saparbayev

Identification of isomeric biomolecules remains a challenging analytical problem. A recently developed spectroscopic method that combines UV photofragmentation and mass spectrometry for fingerprinting of cold ions (2D UV-MS), has already demonstrated its h ...

2021

Molecular-Level Transformation of Dissolved Organic Matter during Oxidation by Ozone and Hydroxyl Radical

Urs von Gunten

Ozonation of drinking and wastewater relies on ozone (O-3) and hydroxyl radical ((OH)-O-center dot) as oxidants. Both oxidants react with dissolved organic matter (DOM) and alter its composition, but the selectivity of the two oxidants and mechanisms of re ...

AMER CHEMICAL SOC2020

Near-infrared reversible photoswitching of an isolated azobenzene-stilbene dye

Eduardo Carrascosa Casado

Photoswitching of a charged azobenzene-stilbene dye is investigated through laser excitation in a tandem ion mobility mass spectrometer. Action spectra associated with E -> Z and Z -> E photoisomerisation of the stilbene group exhibit bands at 685 and 440 ...

Elsevier2020

Bootstrapping massive quantum field theories

João Miguel Augusto Penedones Fernandes, Denis Karateev

We propose a new non-perturbative method for studying UV complete unitary quantum field theories (QFTs) with a mass gap in general number of spacetime dimensions. The method relies on unitarity formulated as positive semi-definiteness of the matrix of inne ...

Springer Nature2020

First Observation of Excited Omega(-)(b) States

Jian Wang, Mingkui Wang, Olivier Schneider, Zhirui Xu, Yiming Li, Yi Zhang, Lei Zhang, Yi Wang, Aurelio Bay, Guido Haefeli, Jessica Prisciandaro, Tatsuya Nakada, Christoph Frei, Mark Tobin, Frédéric Blanc, Greig Alan Cowan, Maurizio Martinelli, Vladislav Balagura, Donal Patrick Hill, Liang Sun, François Fleuret, Mirco Dorigo, Liupan An, Chitsanu Khurewathanakul, Renato Quagliani, Hang Yin, Aravindhan Venkateswaran, Elena Graverini, Michel De Cian, Vladimir Macko, Federico Leo Redi, Luis Miguel Garcia Martin, Sebastian Schulte, Tommaso Colombo, Vitalii Lisovskyi, Tara Nanut, Minh Tâm Tran, Violaine Bellée, Guillaume Max Pietrzyk, Pavol Stefko, Pietro Marino, Maria Vieites Diaz, Lino Ferreira Lopes, Matthieu Philippe Luther Marinangeli, Veronica Sølund Kirsebom, Maria Elena Stramaglia, Ana Bárbara Rodrigues Cavalcante, Guido Andreassi, Luca Pescatore, Preema Rennee Pais, Maxime Schubiger, Plamen Hristov Hopchev, Thi Dung Nguyen, Alison Maria Tully, Olivier Göran Girard, Mâu Chung Nguyên, Axel Kuonen, Vincenzo Battista, Brice Emile Maurin

We report four narrow peaks in the Xi K-0(b)- mass spectrum obtained using pp collisions at center-of-mass energies of 7, 8, and 13 TeV, corresponding to a total integrated luminosity of 9 fb(-1) recorded by the LHCb experiment. Referring to these states b ...

AMER PHYSICAL SOC2020

Observation of a new baryon state in the Lambda(0)(b)pi(+)pi(-) mass spectrum

Jian Wang, Mingkui Wang, Olivier Schneider, Zhirui Xu, Yiming Li, Yi Zhang, Lei Zhang, Yi Wang, Aurelio Bay, Guido Haefeli, Jessica Prisciandaro, Tatsuya Nakada, Christoph Frei, Mark Tobin, Frédéric Blanc, Greig Alan Cowan, Maurizio Martinelli, Vladislav Balagura, Donal Patrick Hill, Liang Sun, François Fleuret, Mirco Dorigo, Liupan An, Renato Quagliani, Hang Yin, Maria Vieites Diaz, Aravindhan Venkateswaran, Elena Graverini, Michel De Cian, Vladimir Macko, Federico Leo Redi, Luis Miguel Garcia Martin, Sebastian Schulte, Tommaso Colombo, Vitalii Lisovskyi, Tara Nanut, Minh Tâm Tran, Violaine Bellée, Guillaume Max Pietrzyk, Pavol Stefko, Pietro Marino, Lino Ferreira Lopes, Matthieu Philippe Luther Marinangeli, Veronica Sølund Kirsebom, Maria Elena Stramaglia, Ana Bárbara Rodrigues Cavalcante, Guido Andreassi, Luca Pescatore, Preema Rennee Pais, Maxime Schubiger, Plamen Hristov Hopchev, Chitsanu Khurewathanakul, Thi Dung Nguyen, Olivier Göran Girard, Mâu Chung Nguyên, Axel Kuonen, Vincenzo Battista, Conor Thomas Fitzpatrick, Michael Thompson McCann

A new baryon state is observed in the Lambda(0)(b)pi(+)pi(-) mass spectrum with high significance using a data sample of pp collisions, collected with the LHCb detector at centre-of-mass energies root s = 7, 8 and 13 TeV, corresponding to an integrated lum ...

Springer Nature2020

Publications associées (30)

Combining ion mobility spectrometry and cryogenic ion spectroscopy with enzymatic digestion/synthesis for the study of N-linked glycans

Irina Märki

EPFL2023

A gas phase approach for glycan analysis: Combining ultrahigh-resolution ion mobility spectrometry with cryogenic vibrational spectroscopy

Ahmed Ben Faleh

EPFL2021

Analyzing glycans cleaved from a biotherapeutic protein using a combination of ion mobility spectrometry and cryogenic ion spectroscopy

Natalia Yalovenko

EPFL2021

Jian Wang, Mingkui Wang, Olivier Schneider, Zhirui Xu, Yiming Li, Yi Zhang, Lei Zhang, Yi Wang, Aurelio Bay, Guido Haefeli, Jessica Prisciandaro, Tatsuya Nakada, Christoph Frei, Mark Tobin, Frédéric Blanc, Greig Alan Cowan, Maurizio Martinelli, Vladislav Balagura, Donal Patrick Hill, Liang Sun, François Fleuret, Mirco Dorigo, Liupan An, Renato Quagliani, Hang Yin, Maria Vieites Diaz, Aravindhan Venkateswaran, Elena Graverini, Michel De Cian, Vladimir Macko, Federico Leo Redi, Luis Miguel Garcia Martin, Sebastian Schulte, Tommaso Colombo, Vitalii Lisovskyi, Tara Nanut, Minh Tâm Tran, Violaine Bellée, Guillaume Max Pietrzyk, Pavol Stefko, Pietro Marino, Lino Ferreira Lopes, Matthieu Philippe Luther Marinangeli, Veronica Sølund Kirsebom, Maria Elena Stramaglia, Ana Bárbara Rodrigues Cavalcante, Guido Andreassi, Luca Pescatore, Preema Rennee Pais, Maxime Schubiger, Plamen Hristov Hopchev, Chitsanu Khurewathanakul, Thi Dung Nguyen, Olivier Göran Girard, Mâu Chung Nguyên, Axel Kuonen, Vincenzo Battista, Conor Thomas Fitzpatrick, Michael Thompson McCann

Springer Nature2020