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Concept

Compteur Coulter

Publications associées (25)

Microfluidic devices

Matthias Lütolf, Jisoo Park

The present disclosure relates to a microfluidic device comprising: a substrate; a culture chamber (130); a loading channel (170) in fluid communication with the culture chamber; at least one auxiliar channel (170-1, 5 170-2) extending from and in fluid co ...

2023

Portable impedance-sensing device for microorganism characterization in the field

Sandro Carrara

A variety of biosensors have been proposed to quickly detect and measure the properties of individual microorganisms among heterogeneous populations, but challenges related to cost, portability, stability, sensitivity, and power consumption limit their app ...

Nature Portfolio2023

Fabrication of micrometer-sized drops as templates for particles

Mathias Steinacher

Drops are omnipresent in our daily life for example in the form of rain drops or as oil drops in a salad dressing. On a technological basis, drops can be used to conduct chemical or biological reactions. These drops often serve as templates to produce mate ...

EPFL2021

Design and fabrication of a vigorous "cavitation-on-a-chip" device with a multiple microchannel configuration

Luis Guillermo Villanueva Torrijo, Mohammad Jafarpour

Hydrodynamic cavitation is one of the major phase change phenomena and occurs with a sudden decrease in the local static pressure within a fluid. With the emergence of microelectromechanical systems (MEMS), high-speed microfluidic devices have attracted co ...

SPRINGERNATURE2021

Impedance-Based Single-Cell Pipetting

Philippe Renaud, Yann Barrandon, Jean-Baptiste Bureau, David Vincent Bonzon, Georges Muller, Nicolas Jean Bernard Beuchat, Nicolas Uffer

Many biological methods are based on single-cell isolation. In single-cell line development, the gold standard involves the dilution of cells by means of a pipet. This process is time-consuming as it is repeated over several weeks to ensure clonality. Here ...

SAGE PUBLICATIONS INC2020

Positional dependence of particles and cells in microfluidic electrical impedance flow cytometry: origin, challenges and opportunities

Philippe Renaud, Jonathan Bastien Cottet, Miguel Solsona Alarcon

Microfluidic electrical impedance flow cytometry is now a well-known and established method for single-cell analysis. Given the richness of the information provided by impedance measurements, this non-invasive and label-free approach can be used in a wide ...

2020

Dynamic response of a compressible binary fluid mixture

Ignacio Pagonabarraga Mora

Binary fluids are present in a wide variety of systems at microscales, such as microfluidic devices containing drops, fluids with air bubbles trapped in them, and devices designed to mix fluids or to make two fluid substances react. Microfluidics devices a ...

2020

How to improve the sensitivity of coplanar electrodes and micro channel design in electrical impedance flow cytometry: a study

Philippe Renaud, Harald Van Lintel, Jonathan Bastien Cottet

This paper describes a comprehensive analysis of the geometrical parameters in uencing the sensitivity of a coplanar elec- trode layout for electrical impedance ow cytometry. The designs presented in this work have been simulated, fabricated, and tested. 3 ...

2019

Deformation of Microchannels Embedded in an Elastic Medium

Vivek Ramachandran

The deformation of microfluidic channels in a soft elastic medium has a central role in the operation of lab-on-a-chip devices, fluidic soft robots, liquid metal (LM) electronics, and other emerging soft-matter technologies. Understanding the influence of ...

ASME2018

Impedance Spectroscopy for Single Cell Analysis and Dispensing

David Vincent Bonzon

Flow cytometry is an essential tool in biology and medicine with applications in immunodeficiency diagnostic, immunosurveillence, organ transplantation in addition to its basic research usage. Before the widespread use of the Fluorescent-Activated Cell Sor ...

EPFL2017

Devices, systems and methods for dispensing and analysing particles

Philippe Renaud, Yann Barrandon, David Vincent Bonzon, Jean-Baptiste Bureau

The present invention relates to a pipette tip comprising a thin holed membrane at its distal end, which is designed to be adapted with a system comprising at least an impedance analyser and a fluidic actuator to perform the dispensing and analysis of part ...

2016

Microfluidic-integrated vertical electrodes employed in impedance-based cytometry : potential application in immunotherapies

Enrica Rollo

During the last decades, the growing interest for single-cell analysis has led to the creation of a number of microfluidic and lab-on-a chip (LOC) platforms for characterizing cellular samples. In that context label-free based platforms are minimally invas ...

EPFL2016

Modeling, Simulation, and Performance Evaluation of a Novel Microfluidic Impedance Cytometer for Morphology-Based Cell Discrimination

Philippe Renaud, Ludovica Colella, Marjan Shaker

The performance of a novel microfluidic impedance cytometer [1] for single-cell analysis is investigated in-silico by means of a finite element model. The main feature of the device is the ability to probe impedance of flowing cells along two orthogonal di ...

Institute of Electrical and Electronics Engineers2014

Image-Derived Input Function from the Vena Cava for 18F-FDG PET Studies in Rats and Mice

Rolf Gruetter, Bernard Lanz, Carole Poitry-Yamate

Measurement of arterial input function is a restrictive aspect for quantitative 18F-FDG PET studies in rodents because of their small total blood volume and the related difficulties in withdrawing blood. METHODS: In the present study, we took advantage of ...

Soc Nuclear Medicine Inc2014

Single microbe trap and release in sub-microfluidics

Andreas Vasdekis

Life on Earth is comprised mostly of microbes with significant implications in disease and carbon cycling. However, their dimensions and mobility make microbes challenging to analyse on-chip. A sub-micron resolution microfluidic system (sub-microfluidics) ...

Royal Soc Chemistry2013

Cell viability assessment by flow cytometry using yeast as cell model

Philippe Renaud, Niccolo Piacentini, Nina Buffi

This paper reports the new combination of cell sorting and counting capabilities on a single device. Most state-of-the-art devices combining these technologies use optical techniques requiring complicated experimental setups and labeled samples. The use of ...

Elsevier2011

Separation and Focusing of Magnetic Beads for Agglutination Tests

Rana Afshar Ghasemlouy

Functional magnetic micro- and nanoparticles are used in bioanalytical applications as solid carriers for capture, transport and detection of biomolecules or magnetically labeled cells. Colloidal suspensions of such particles provide a large specific surfa ...

EPFL2011

Three-Dimensional Magnetic Focusing of Superparamagnetic Beads for On-Chip Agglutination Assays

Martinus Adela Maria Gijs, Thomas Lehnert, Rana Afshar Ghasemlouy

We present a new method for three-dimensional (3D) magnetic focusing of magnetic microparticles in a microfluidic system. On-chip magnetic particle manipulation in themicrochannel is achieved by a high-gradientmagnetic field generated by means of a microma ...

2011

Individual cells immobilization for water-borne pathogen detection and enumeration

A cell counting device has been proposed and implemented for water-borne pathogen detection for drinking water quality monitoring applications. Our approach is based on magnetically-labelled cells immobilization in a high density array of individual cell f ...

Elsevier Science, Reg Sales Off, Customer Support Dept, 655 Ave Of The Americas, New York, Ny 10010 Usa2009

Dielectrophoresis-based continuous-flow particle microreactor

This thesis mainly deals with the integration of a microfluidic system for the extraction of micrometric and submicrometric particles from a solution. Traditional methods take from several minutes to hours to separate particles from a solution. Microfluidi ...

EPFL2009