Mediaspace scheduled maintenance: Aug 25, 2026 07:00 - 12:00 AM. During this time, videos will be temporarily unavailable. Check status updates.

Concept

Bibliothèque numérique

Publications associées (21)

Querying the Digital Archive of Science: Distant Reading, Semantic Modelling and Representation of Knowledge

Alina Volynskaya

The archive of science is a place where scientific practices are sedimented in the form of drafts, protocols of rejected hypotheses and failed experiments, obsolete instruments, outdated visualizations and other residues. Today, just as science goes more a ...

EPFL2024

Fine Arts in Transition: An Operative Research and Teaching Approach between Analogue and Digital

Nicola Braghieri, Filippo Fanciotti

The volume collects the material produced for the exhibition 'The Sky in the Room' and a selection of scientific texts on the question of analogue continuity in digital transition. The contributions will be focused on verifying the operative method in teac ...

EPFL Press2024

Ontology-based Knowledge Representation for Traditional Martial Arts

Sarah Irene Brutton Kenderdine, Yumeng Hou

Traditional martial arts are treasures of humanity's knowledge and critical carriers of sociocultural memories throughout history. However, such treasured practices have encountered various challenges in knowledge transmission and now feature many entries ...

2024

Discovery of macrocyclic inhibitors of challenging protein-protein interactions

Edward Jeffrey Will

Macrocycles are a therapeutic modality of interest for drugging challenging disease targets due to their high binding affinity and membrane permeability, enabling the discovery of orally delivered and efficacious therapeutics. Recent methods have enabled t ...

EPFL2024

On Artificial Intelligence and Manipulation

Marcello Ienca

The increasing diffusion of novel digital and online sociotechnical systems for arational behavioral influence based on Artificial Intelligence (AI), such as social media, microtargeting advertising, and personalized search algorithms, has brought about ne ...

SPRINGER2023

Genetic Algorithms for the Discovery of Homogeneous Catalysts

Anne-Clémence Corminboeuf, Rubén Laplaza Solanas, Simone Gallarati, Puck Elisabeth van Gerwen, Alexandre Alain Schöpfer

In this account, we discuss the use of genetic algorithms in the inverse design process of homogeneous catalysts for chemical transformations. We describe the main components of evolutionary experiments, specifically the nature of the fitness function to o ...

2023

Technology Mapping Using Multi-output Library Cells

Giovanni De Micheli, Alessandro Tempia Calvino

Technology mapping transforms a technology-independent representation into a technology-dependent one given a library of cells. Even if technology libraries contain multi-output cells, state-of-the-art techniques fully exploit single-output cells only. Mul ...

2023

Design of an artificial phage-display library based on a new scaffold improved for average stability of the randomized proteins

Ghérici Hassaïne

Scaffold-based protein libraries are designed to be both diverse and rich in functional/folded proteins. However, introducing an extended diversity while preserving stability of the initial scaffold remains a challenge. Here we developed an original approa ...

Nature Portfolio2023

PMT: Power Measurement Toolkit

Emma Elizabeth Tolley

Efficient use of energy is essential for today's supercomputing systems, as energy cost is generally a major component of their operational cost. Research into "green computing" is needed to reduce the environmental impact of running these systems. As such ...

IEEE COMPUTER SOC2022

De novo developed small cyclic peptides that are orally available

Manuel Leonardo Merz

Cyclic peptides are ring-shaped molecules that emerged as a promising class of therapeutics. While it is often difficult to find small molecule binders for challenging disease targets, cyclic peptides can bind to featureless surfaces or inhibit protein-pro ...

EPFL2022

Generating macrocyclic inhibitors of protein-protein interactions

Gontran Sangouard

Protein-protein interactions (PPIs) play important roles in many diseases and their modulation is an attractive strategy for developing new therapeutics. However, the relatively large and often flat binding surfaces of PPIs makes the development of inhibit ...

EPFL2022

Patron-Driven Acquisition et Evidence-Based Acquisition: Comment implémenter ces modèles afin d’étendre l’offre documentaire dans une bibliothèque ?

Manon Velasco, Marion Favre

Nowadays, usage-based acquisition models for e-books, as PDA and EBA, are quite spread and allow libraries to offer wider collections, without acquiring them. A PDA with Ebook Central was implemented in 2019 and a first EBA with Wiley in 2021. The EPFL Lib ...

Liège Université Library2023

Methods for the generation of large combinatorial macrocycle libraries

Sevan Mleh Habeshian

Macrocycles are an attractive class of molecules due to their good binding properties and yet rather small size that allows, in many cases, crossing membranes to reach intracellular targets. In comparison to classical small molecule drugs, macrocycles are ...

EPFL2021

Energym: A Building Model Library for Controller Benchmarking

Tomasz Tadeusz Gorecki, Paul Scharnhorst

We introduce the Python-based open-source library Energym, a building model library to test and benchmark building controllers. The incorporated building models are presented with a brief explanation of their function, location and technical equipment. Fur ...

2021

Archiving the Leftovers of Science: Metadata and Histories of Scientific Institutions

Alina Volynskaya

In this article, I focus on digital scientific archives which are made up of the leftovers of science, such as drafts, obsolete instruments, photographs, documentation, etc. The artifacts exhibited in such collections were neither meant to be representatio ...

2021

Computational Archives for Experimental Museology

Sarah Irene Brutton Kenderdine, Lillian Hibberd

This article addresses the potential for computational practises within archival and museological domains by charting a positional shift occurring in digital archives; from working with an object orientation and containment – to computing with a dimension ...

2021

Accessing, Representing, and Transmitting Cultural Heritage through Digital Archives: challenges and opportunities

Yumeng Hou

Digitization has been recognized as effective means to safeguard cultural heritage,simultaneously producing a significant body of data resources within the GLAM sector. Digital curatorial innovations in the museums have created tools to enhance accessibili ...

2021

Impact of Digital and Non-Digital Urban Participatory Approaches on Public Access Conditions: An Evaluation Framework

Jens Ingensand, Thibaud Nicolas Chassin

The gradual institutionalization of public participation increasingly compels local authorities to partially share their power over the transformation of urban areas. The smooth running of a participatory session is based on selecting the appropriate type ...

MDPI2021

Radical Intangibles: Materializing the Ephemeral

Sarah Irene Brutton Kenderdine, Lillian Hibberd

New materialism considers that the world and its histories are produced by a range of material forces that extend from the physical and the biological to the psychological, social and cultural. In recognizing that heritage is not held in objects alone, new ...

2021

Too Quiet in the Library: An Empirical Study of Security Updates in Android Apps' Native Code

Mathias Josef Payer

Android apps include third-party native libraries to increase performance and to reuse functionality. Native code is directly executed from apps through the Java Native Interface or the Android Native Development Kit. Android developers add precompiled nat ...

IEEE COMPUTER SOC2021