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Concept

Espérance de vie humaine

Publications associées (28)

A microfluidic platform for automated phenotyping during full lifespan of Caenorhabditis elegans at high-throughput

Martinus Adela Maria Gijs, Johan Auwerx, Matteo Cornaglia, Laurent Mouchiroud, Hüseyin Baris Atakan

We present a multiplexed and automated microfluidic platform for phenotyping of C. elegans during their full lifespan and at high-throughput. We used the fluorescent hsp-6::gfp strain of worms and performed experiments to observe the effect of four differe ...

2017

Modulating NAD(+) metabolism, from bench to bedside

Johan Auwerx, Elena Katsyuba

Discovered in the beginning of the 20(th) century, nicotinamide adenine dinucleotide (NAD(+)) has evolved from a simple oxidoreductase cofactor to being an essential cosubstrate for a wide range of regulatory proteins that include the sirtuin family of NAD ...

Wiley2017

The References of References: Enriching Library Catalogs via Domain-Specific Reference Mining

Frédéric Kaplan, Matteo Romanello, Giovanni Colavizza

The advent of large-scale citation services has greatly impacted the retrieval of scientific information for several domains of research. The Humanities have largely remained outside of this shift despite their increasing reliance on digital means for info ...

2016

Tracking residence times in hydrological systems: forward and backward formulations

Andrea Rinaldo, Paolo Benettin

In recent years, several papers contributed to the development and clarification of key theoretical issues underlying the formulation of transport by travel time distributions in catchments. Such a formulation provides a robust description of the temporal ...

Wiley-Blackwell2015

Mitochondrial ribosomal proteins as aging regulators

Johan Auwerx, Laurent Mouchiroud, Richardus Houtkooper

The present invention relates to methods of increasing lifespan, delaying aging, and/or preventing or treating an age-related disease or a mitochondrialdisease in a subject, comprising inducing a nuclear-mitochondrial OXPHOS protein dyssynchrony, including ...

2013

Identification of genetic determinants and pharmacological modulators of mitochondrial function

Pénélope Andreux

Increased life expectancy goes hand in hand with a higher incidence of age-related diseases that affect the nervous and metabolic systems, such as type 2 diabetes, cancer, Parkinson’s and Alzheimer’s disease. These complex diseases are a product of the com ...

EPFL2013

Closing the gap between T-cell life span estimates from stable isotope-labeling studies in mice and humans

Istvan Bartha

Quantitative knowledge of the turnover of different leukocyte populations is a key to our understanding of immune function in health and disease. Much progress has been made thanks to the introduction of stable isotope labeling, the state-of-the-art techni ...

Amer Soc Hematology2013

Development of an Assistive Motorized Hip Orthosis

Hannes Bleuler, Mohamed Bouri, Reymond Clavel, Jeremy Olivier, Amalric Louis Ortlieb

With the increase of life expectancy, a higher number of elderly need assistance to maintain their mobility and their independance. The hip joint is crucial for walking and is problematic for a large number of aged people. In this paper we present a novel ...

2013