This article outlines the history of natural scientific research in Canada, including physics, astronomy, space science, geology, oceanography, chemistry, biology, and medical research. Neither the social sciences nor the formal sciences are treated here. The early European explorers were responsible for charting much of what would become the east and west coasts of Canada as well as the Arctic. John Cabot, the Italian explorer sailing under the English flag made two voyages to North America in 1497 and 1498 along the coast of what is now called Newfoundland. Gaspar Corte-Real, the Portuguese explorer, is thought to have explored the area along the Newfoundland, Labrador and Greenland coasts in 1500 and 1501. In 1524, Giovanni da Verrazzano sailing under the French flag, explored the east coast of North America from Cape Fear to Newfoundland. During voyages of exploration in 1534 and 1535–1536, the French explorer Jacques Cartier "discovered" and mapped the St. Lawrence River as far inland as Hochelaga (Montreal). Samuel de Champlain is well known for his explorations of the St Lawrence and Acadia, in 1603 and 1604. The search for fabled Northwest Passage to the orient intrigued European explorers for 300 years. The first efforts in this regard were made by British explorers Martin Frobisher in 1576 and by John Davis in 1585. In 1610 Henry Hudson made his ill-fated voyage in search of the Passage. William Baffin and Robert Bylot sailed the Arctic sea in the area around what became known as Baffin Island in 1616. While these voyages not successful, in that they did not discover the Northwest Passage, they provided valuable information on the nature of the Arctic Ocean. Voyages by William Edward Parry in 1819 and John Ross in 1829 added to the growing body of knowledge relating to the north. The Hudson's Bay Company also played a role in Arctic exploration and during the period 1837–1839, Peter Warren Dease and Thomas Simpson of that company explored the Arctic coast from Point Barrow to Rae Strait.