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Concept

Channelrhodopsin

Publications associées (22)

Stimulation of medial amygdala GABA neurons with kinetically different channelrhodopsins yields opposite behavioral outcomes

Ralf Schneggenburger, Olexiy Kochubey, Aiste Baleisyte

The medial amygdala (MeA) receives pheromone information about conspecifics and has crucial functions in social behaviors. A previous study showed that activation of GABA neurons in the postero-dorsal MeA (MeApd) with channelrhodopsin-2(H)(134R) (ChR2) sti ...

CELL PRESS2022

An optimized protocol for assessing changes in mouse whole-brain activity using opto-fMRI

Valerio Zerbi, Christina Maria Grimm

Functional magnetic resonance imaging (fMRI) in mouse brain, paired with spatially and temporally defined manipulations, offers a powerful tool to causally explain the effect of specific neuronal activity on brain network dynamics. Here, we present an opti ...

ELSEVIER2022

The role of medial amygdala inhibitory neurons in regulating social behavior

Aiste Baleisyte

Aggression is an evolutionary conserved social behavior that is necessary for an animalÂŽs survival. The neural substrates coordinating aggression are known to exist in the amygdala and the hypothalamus. While the medial amygdala (MeA) and the ventrolatera ...

EPFL2021

Optogenetic control of Neisseria meningitidis Cas9 genome editing using an engineered, light-switchable anti-CRISPR protein

Bruno Emanuel Ferreira De Sousa Correia, Zander Harteveld

Optogenetic control of CRISPR-Cas9 systems has significantly improved our ability to perform genome perturbations in living cells with high precision in time and space. As new Cas orthologues with advantageous properties are rapidly being discovered and en ...

2021

Combining Optogenetic Stimulation and Motor Training Improves Functional Recovery and Perilesional Cortical Activity

Silvestro Micera

Background. An ischemic stroke is followed by the remapping of motor representation and extensive changes in cortical excitability involving both hemispheres. Although stimulation of the ipsilesional motor cortex, especially when paired with motor training ...

SAGE PUBLICATIONS INC2021

Optogenetic Stimulation of Basal Forebrain Parvalbumin Neurons Activates the Default Mode Network and Associated Behaviors

Ralf Schneggenburger, Michael Kintscher, Jayakrishnan Harikrishnavilas Raveendran Nair, Laura Lozano Montes

Activation of the basal forebrain (BF) has been associated with increased attention, arousal, and a heightened cortical representation of the external world. In addition, BF has been implicated in the regulation of the default mode network (DMN) and associ ...

2020

Glucose transporter 2 mediates the hypoglycemia-induced increase in cerebral blood flow

Rolf Gruetter, Hongxia Lei

Glucose transporter 2 (Glut2)-positive cells are sparsely distributed in brain and play an important role in the stimulation of glucagon secretion in response to hypoglycemia. We aimed to determine if Glut2-positive cells can influence another response to ...

2019

Optimized photo-stimulation of halorhodopsin for long-term neuronal inhibition

Chuanqiang Zhang

Background Optogenetic silencing techniques have expanded the causal understanding of the functions of diverse neuronal cell types in both the healthy and diseased brain. A widely used inhibitory optogenetic actuator is eNpHR3.0, an improved version of the ...

2019

Untangling emergent cortical dynamics: neurons from networks, noise from chaos

Max Christian Nolte

The way in which cortical microcircuit components -- most importantly neurons -- and their connectivity -- the network -- shape and constrain emergent dynamics is a long-standing question in neuroscience. Experimentally observed dynamical properties can of ...

EPFL2019

Soft multimodal neural interfaces for unravelling sensory neurological circuits

Frédéric Pierre Gérald Michoud

Diseases or injuries affecting the nervous system can dramatically disrupt the quality of life. Despite extensive efforts towards treating dysfunctional nervous systems, the pharmacological and electrical approaches generally involved lack the temporal and ...

EPFL2019

Optogenetic Peripheral Nerve Immunogenicity

Optogenetic technologies have been the subject of great excitement within the scientific community for their ability to demystify complex neurophysiological pathways in the central (CNS) and peripheral nervous systems (PNS). The excitement surrounding opto ...

Nature Research2018

Layer, cell-type and pathway-specific thalamocortical input to mouse somatosensory cortex

Berat Semihcan Sermet

In the mouse whisker system, sensory information is relayed to the whisker somatosensory cortex by two major thalamic nuclei, the ventral posterior medial nucleus (VPM) and the posterior medial nucleus (POM). While the cortical axonal innervation pattern o ...

EPFL2018

CuInGaS2 photocathodes treated with SbX3 (X = Cl, I): the effect of the halide on solar water splitting performance

Kevin Sivula, Nestor Guijarro Carratala, Florian Le Formal, Xavier Adrian Jeanbourquin, Xiaoyun Yu, Mathieu Steven Prévot, Melissa Catherine Olson, Pauline Bornoz, Wiktor Stefan Bourée

The realization of photoelectrochemical tandem cells for efficient solar-to-hydrogen energy conversion is currently impeded by the lack of inexpensive, stable, and efficient photocathodes. The family of sulfide chalcopyrites (CuInxGa1-xS2) has recently dem ...

Iop Publishing Ltd2017

Polarizable embedding with a multiconfiguration short-range density functional theory linear response method

We present here the coupling of a polarizable embedding (PE) model to the recently developed multiconfiguration short-range density functional theory method (MC-srDFT), which can treat multiconfigurational systems with a simultaneous account for dynamical ...

Amer Inst Physics2015

Detection of Optogenetic Stimulation in Somatosensory Cortex by Non-Human Primates - Towards Artificial Tactile Sensation

Fabien Bertrand Paul Wagner, David Allenson Borton

Neuroprosthesis research aims to enable communication between the brain and external assistive devices while restoring lost functionality such as occurs from stroke, spinal cord injury or neurodegenerative diseases. In future closed-loop sensorimotor prost ...

Public Library of Science2014

Single-nanowire solar cells beyond the Shockley-Queisser limit

Anna Fontcuberta i Morral, Martin Heiss

Light management is of great importance in photovoltaic cells, as it determines the fraction of incident light entering the device. An optimal p-n junction combined with optimal light absorption can lead to a solar cell efficiency above the Shockley-Queiss ...

Nature Publishing Group2013

Identification of the factors affecting co-localization precision for quantitative multicolor localization microscopy

Aleksandra Radenovic, Paolo Annibale, Marco Scarselli

This work explores the potential of multi-color Photoactivated Localization Microscopy (PALM) imaging to probe sub-diffraction limit interactions between proteins with spectrally separated labels. Using a PALM setup built around a commercial microscope axi ...

SpringerOpen2012

Microcircuits of excitatory and inhibitory neurons in layer 2/3 of mouse barrel cortex

Wulfram Gerstner, Carl Petersen, Céline Matéo, Michael Avermann, Christian Tomm

Avermann M, Tomm C, Mateo C, Gerstner W, Petersen CC. Microcircuits of excitatory and inhibitory neurons in layer 2/3 of mouse barrel cortex. J Neurophysiol 107: 3116-3134, 2012. First published March 7, 2012; doi:10.1152/jn.00917.2011.-Synaptic interactio ...

American Physiological Society2012

Optogenetic Probing of Cortical Synaptic Circuits Measured Through in Vivo Whole-Cell Recordings in the Mouse Barrel Cortex

Céline Matéo

Although neocortex underlies higher-order brain functions, little is known about the synaptic interactions that drive neocortical microcircuit function in vivo. The neocortex is spontaneously active in vivo so I explored how such spontaneous network activi ...

EPFL2011

In Vivo Optogenetic Stimulation of Neocortical Excitatory Neurons Drives Brain-State-Dependent Inhibition

Carl Petersen, Céline Matéo, Michael Avermann

Background: Synaptic interactions between excitatory and inhibitory neocortical neurons are important for mammalian sensory perception. Synaptic transmission between identified neurons within neocortical microcircuits has mainly been studied in brain slice ...

Elsevier2011