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Concept

Squelette humain

Publications associées (24)

Intrinsic viscoelasticity increases temperature in knee cartilage under physiological loading

Dominique Pioletti, Philippe Abdel Sayed, Mohamadreza Nassajian Moghadam

Metabolism of proteoglycans and hyaluronic acid has been shown to be temperature- dependent in cartilage explants, with optimal anabolic effects between 36 1C and 38 1C. At rest, the temperature of human knee has a value of around 33 1C. We aim to show in ...

Elsevier2014

Dissipation as variable in cartilage mechanobiology

Philippe Abdel Sayed

Mechanobiology is the analysis of the role of mechanical forces in educing a molecular response in cells. Nowadays, mechanobiology may contribute to clinical progress. In particular, mechanical stimulation has been proposed to induce chondrogenesis in engi ...

EPFL2013

Combined effects of zoledronate and mechanical stimulation on bone adaptation in an axially loaded mouse tibia

Dominique Pioletti, Vincent Stadelmann

Background: Local bisphosphonate delivery may be a solution to prevent periprosthetic bone loss and improve orthopedic implants fixation. In load-bearing implants, periprosthetic bone is exposed to high mechanical demands, which in normal conditions induce ...

Elsevier2011

Surgical preparation of bone-scaffold interface is critical for bone regeneration inside tissue engineering scaffold

Dominique Pioletti, Alireza Roshan Ghias

The goal of this study was to investigate if the preparation of implantation site has an impact on bone formation inside tissue engineering scaffolds. For this purpose, two different drilling techniques were used to create a hole in distal femurs of rats b ...

Wiley-Blackwell2011