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Concept

Biocompatibilité

Publications associées (26)

Biodegradable Implantable Microsystems

Jürgen Brugger, Jongeon Park

Biodegradable implanted devices and microsystems are candidates to fulfill the utmost required in-vivo assistance for a variety of envisioned bio-medical health care applications. They range from monitoring biomarkers, recording, and stimulation, to local ...

IEEE2023

A Sustainable Printed Chitosan-Based Sensor for Acetone Detection

Sandro Carrara, Johanna Zikulnig

Biomedical sensing applications, including breath analysis, contribute to increasing the amount of electronic waste, as the sensors are frequently disposed, due to hygienic considerations. Consequently, the development of sustainable sensor solutions is cr ...

IEEE2023

Polysaccharide Layer-by-Layer Coating for Polyimide-Based Neural Interfaces

Silvestro Micera

Implantable flexible neural interfaces (IfNIs) are capable of directly modulating signals of the central and peripheral nervous system by stimulating or recording the action potential. Despite outstanding results in acute experiments on animals and humans, ...

MDPI2022

Mechanical reinforcement of granular hydrogels

Esther Amstad, Alvaro Lino Boris Charlet, Francesca Bono

Granular hydrogels are composed of hydrogel-based microparticles, so-called microgels, that are densely packed to form an ink that can be 3D printed, injected or cast into macroscopic structures. They are frequently used as tissue engineering scaffolds bec ...

ROYAL SOC CHEMISTRY2022

A new versatile hybrid MEMS technology for high sensitivity, fluid proof sensing applications

Matthias Neuenschwander

The field of micro electromechanical systems (MEMS) evolved from the microelectronic industry and the technologies developed to fabricate integrated circuits. As a result, MEMS are commonly fabricated on silicon wafers. The development of MEMS has been dri ...

EPFL2022

Laser-induced liquid micro-jets for drug delivery

Jan Krizek

Jet injection devices have been studied and developed for transdermal drug delivery to avoid the use of needles. Such contact-less devices provide several advantages such as better dose control, lateral and depth localisation, lower collateral damage than ...

EPFL2021

Atomistic simulation and electron microscopy to characterize grain boundaries in doped beta-tricalcium phosphate ceramics

Gabrielle Anne Laguisma Sblendorio

The limitations and potential complications correlated with autogenous bone grafts have raised interest in the development of synthetic bone graft substitutes. ß-tricalcium phosphate (ß-TCP) is one of the most promising materials for synthetic bone graft s ...

EPFL2021

An Overview of Serum Albumin Interactions with Biomedical Alloys

Stefano Mischler, Anna Neus Igual Muñoz, Oksana Klok

Understanding the interactions between biomedical alloys and body fluids is of importance for the successful and safe performance of implanted devices. Albumin, as the first protein that comes in contact with an implant surface, can determine the biocompat ...

2020

Transient Electronics: Biodegradable Frequency‐Selective Magnesium Radio‐Frequency Microresonators for Transient Biomedical Implants (Adv. Funct. Mater. 39/2019)

Jürgen Brugger, Giovanni Boero, Matthieu Jean Michel Rüegg

In article number 1903051, Matthieu Rüegg, Juergen Brugger, and co-workers design, fabricate, and characterize biodegradable magnesium microresonators using an innovative microfabrication process based on ion beam etching. Under a radio-frequency magnetic ...

2019

Mechanoresponsive Micro- and Nanoparticles

Harm-Anton Klok, Friederike Katharina Metze

Mechanical stimuli are ubiquitous in the human body. In contrast to biochemical stimuli such as pH, redox, hypoxia or enzymes as well as exogenous stimuli such as magnetic fields, temperature or ultrasound, endogenous biomechanical stimuli have only receiv ...

2019

Biodegradable Frequency‐Selective Magnesium Radio‐Frequency Microresonators for Transient Biomedical Implants

Jürgen Brugger, Giovanni Boero, Matthieu Jean Michel Rüegg

Bioresorbable implantable medical devices show a great potential for applications requiring medical care over well‐defined periods of time. Once their function is fulfilled, such implants naturally degrade and resorb in the body, which eliminates adverse l ...

2019

Soft And Wearable Transducers: Opportunities And Challenges For Daily Use

Stéphanie Lacour

Soft bioelectronic interfaces are broadly defined as microfabricated devices, distributed over large-areas, and with mechanical properties suited to comply the soft and dynamic biological tissues. The hybrid integration and processing of materials ranging ...

IEEE2019

Particle suitable for the manufacture of an implantable soft tissue engineering material

Philippe Renaud, Thomas Michael Braschler, Amélie Barbara Hildegarde Béduer

The particle (1) is suitable for the manufacture of an implantable soft tissue engineering material and comprises: a three-dimensionally warped and branched sheet (2) where (i) the three-dimensionally warped and branched sheet (2) is made from a biocompati ...

2019

Wireless Power Transfer and Data Communication for Implantable Autonomous Monitoring and Detection of Epilepsy In Vivo

Kerim Türe

The impact of technological advancement became significant and still has an essential role to play in the diagnosis and treatment of diseases. Nowadays, personalized medicine and therapy are on the rise as a consequence of the developed and cheaper medical ...

EPFL2019

Portable bioluminescence systems and methods for in vivo monitoring of molecular and metabolic events in animals

Elena Goun, Aurélien Godinat, Aleksey Yevtodiyenko

A system for monitoring biological processes in vivo is provided. The system comprises an implantable luciferase biosensor comprising luciferase in a biocompatible matrix and a caged luciferin probe. The caged luciferin probe can be administered to a livin ...

2018

Interaction of biologically relevant ions and organic molecules with titanium oxide (rutile) surfaces: A review on molecular dynamics studies

Paul Bowen, Ulrich Aschauer, Azade Yazdan Yar

The surface of a biomaterial can play a major role in its biological fate since the surface is the primary pathway for its interaction with the body. As the natural response of the body to a foreign material is to encapsulate it with a fibrous material, th ...

2018

Sputtered Gum metal thin films showing bacterial inactivation and biocompatibility

César Pulgarin, Juan Kiwi, Sami Rtimi

Super-elastic Titanium based thin films Ti-23Nb-0.7Ta-2Zr-(O) (TNTZ-O) and Ti-24Nb-(N) (TN-N) (at.%) were deposited by direct current magnetron sputtering (DCMS) in different reactive atmospheres. The effects of oxygen doping (TNTZ-O) and/or nitrogen dopin ...

Elsevier Science Bv2016

Converting disulfide bridges in native peptides to stable methylene thioacetals

Nicolai Cramer, Christopher Matthew Bandeli Kourra

Disulfide bridges play a crucial role in defining and rigidifying the three-dimensional structure of peptides. However, disulfides are inherently unstable in reducing environments. Consequently, the development of strategies aiming to circumvent these defi ...

Royal Soc Chemistry2016

Increasing the stability of nanofluids with cavitating flows in micro orifices

Yusuf Leblebici

One of the most critical challenges for nanofluids in practical applications is related to their stability and reusability since a gradual agglomeration of nanoparticles in nanofluids occurs with time and is accelerated by heating. In this study, we propos ...

Amer Inst Physics2016

Miniaturized Dielectric Elastomer Actuator for Mechanical Stimulation of Monolayer Cell Cultures

Alexandre Poulin

This thesis advances the field of dielectric elastomer actuators (DEAs) through the development of device designs, fabrication processes, strain characterization technique and modelling tool. It provides the first demonstration that DEAs can be interfaced ...

EPFL2016