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Concept

Explosion oxydative

Publications associées (23)

Invasive and indigenous microbiota impact intestinal stem cell activity through multiple pathways in Drosophila

Bruno Lemaitre, Sveta Chakrabarti

Gut homeostasis is controlled by both immune and developmental mechanisms, and its disruption can lead to inflammatory disorders or cancerous lesions of the intestine. While the impact of bacteria on the mucosal immune system is beginning to be precisely u ...

2009

Genetic ablation of Drosophila phagocytes reveals their contribution to both development and resistance to bacterial infection

Bruno Lemaitre

Drosophila phagocytes participate in development and immune responses through their abilities to perform phagocytosis and/or secrete extra-cellular matrix components, antimicrobial peptides, clotting factors and signalling molecules. However, our knowledge ...

2009

Modulation of astrocytic metabolic phenotype by proinflammatory cytokines

Pierre Magistretti, Igor Allaman

Astrocytes play an important role in nervous system homeostasis. In particular, they contribute to the regulation of local energy metabolism and to oxidative stress defence. In previous experiments, we showed that long-term treatment with interleukin 1alph ...

2008