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Concept

Explosion oxydative

Publications associées (23)

Bacterial diversity dominates variable macrophage responses of tuberculosis patients in Tanzania

Jacques Fellay, Zhi Ming Xu

The Mycobacterium tuberculosis complex (MTBC) comprises nine human-adapted lineages that differ in their geographical distribution. Local adaptation of specific MTBC genotypes to the respective human host population has been invoked in this context. We aim ...

Nature Portfolio2024

Mountaintop Gamma Ray Observations of Three Terrestrial Gamma‐Ray Flashes at the Säntis Tower, Switzerland With Coincident Radio Waveforms

Farhad Rachidi-Haeri, Marcos Rubinstein, Antonio Sunjerga, Amirhossein Mostajabi

We report on the mountain top observation of three terrestrial gamma-ray flashes (TGFs) that occurred during the summer storm season of 2021. To our knowledge, these are the first TGFs observed in a mountaintop environment and the first published European ...

2024

Exploring the role of cGAS-STING-mediated inflammation in age-associated neurodegeneration and antitumor immunity

Natasha Ella Samson

Inflammation stands as a dynamic and intricate biological process, promoting vital defence mechanisms against harmful stimuli, including infections and injuries, to drive pathogen clearance and healing. On one hand, these responses can manifest acutely and ...

EPFL2024

Mechanisms and functions of protein S-acylation

Françoise Gisou van der Goot Grunberg, Laurence Gouzi Abrami, Francisco De Magalhães Sarmento Ribeiro De Mesquita

Over the past two decades, protein S-acylation (often referred to as S-palmitoylation) has emerged as an important regulator of vital signalling pathways. S-Acylation is a reversible post-translational modification that involves the attachment of a fatty a ...

Nature Portfolio2024

Intrinsically High Capacity of Animal Cells From a Symbiotic Cnidarian to Deal With Pro-Oxidative Conditions

Gaëlle Delphine Toullec

The cnidarian-dinoflagellate symbiosis is a mutualistic intracellular association based on the photosynthetic activity of the endosymbiont. This relationship involves significant constraints and requires co-evolution processes, such as an extensive capacit ...

FRONTIERS MEDIA SA2022

Quantum Sensing of Free Radicals in Primary Human Dendritic Cells

Mayeul Sylvain Chipaux

Free radicals are crucial indicators for stress and appear in all kinds of pathogenic conditions, including cancer, cardiovascular diseases, and infection. However, they are difficult to detect due to their reactivity and low abundance. We use relaxometry ...

AMER CHEMICAL SOC2022

Single-cell lipidomics reveals a role for cell-to-cell sphingolipid heterogeneity in fibroblast activation

Laura Capolupo

Cell-to-cell variability plays a key role in tissue patterning by setting initial asymmetry that primes cell fate decisions. Fluctuations in the activity of regulatory molecules can commit individual cells to divergent differentiation pathways, and cell-to ...

EPFL2021

Role of Nimrod receptors in the Drosophila melanogaster cellular immune response

Claudia Melcarne

The use of modern molecular biology tools and simple but powerful tractable model organisms such as Drosophila has contributed significantly to our recent advances in the innate immunity field, notably phagocytosis. Since 2001, many phagocytic transmembran ...

EPFL2020

A releasable disulfide-linked peptide tag facilitates the synthesis and purification of short peptides

Christian Heinis, Alessandro Zorzi, Yu Teng Wu

Combinatorial cyclization of hundreds to thousands of random linear peptides by structurally diverse chemical linkers offers access to large macrocyclic compound libraries. A bottleneck in the development of such libraries is the preparation of large numbe ...

Royal Society of Chemistry2020

Reactive species monitoring and their contribution for removal of textile effluent with photocatalysis under UV and visible lights: Dynamics and mechanism

Sami Rtimi

In this study, the photocatalytic activities were investigated for the treatment of Reactive Green 12 (RG 12) solution under UV and visible irradiation using Cu doped TiO2, and TiO2 impregnated on (1) cellulose and (2) UV-C activated polyester catalysts. T ...

ELSEVIER SCIENCE SA2018

Alamandine abrogates neutrophil degranulation in atherosclerotic mice

Nikolaos Stergiopoulos, Rodrigo Araujo Fraga Da Silva

Background Neutrophil-mediated inflammation was recently identified as an active contributor to athero-progression. Therapeutic strategies inhibiting neutrophil degranulation or recruitment were hypothesized to positively impact on plaque vulnerability. In ...

Wiley-Blackwell2017

Red blood cells ageing markers: a multi-parametric analysis

Gerardo Turcatti, Niels Erik Lion, Benjamin Rappaz, Michel Prudent, Manon Sandra Bardyn

Background. Red blood cells collected in citrate-phosphate-dextrose can be stored for up to 42 days at 4 degrees C in saline-adenine-glucose-mannitol additive solution. During this controlled, but nevertheless artificial, ex vivo ageing, red blood cells ac ...

Simti Servizi Srl2017

New insights into ROS dynamics: a multi-layered microfluidic chip for ecotoxicological studies on aquatic microorganisms

Olivier Martin, Christian Santschi, Volodymyr Koman, Nadia Rachel Von Moos

Reactive oxygen species (ROS) play an important role in the life of every cell, including cellular defense and signaling mechanisms. Continuous and quantitative ROS sensing can provide valuable information about the cell state, but it remains a challenge t ...

Informa Healthcare2016

Treatment with the GPR55 antagonist CID16020046 increases neutrophil activation in mouse atherogenesis

Nikolaos Stergiopoulos

Endocannabinoids modulate atherogenesis by triggering different receptors. Recently, orphan G protein-coupled receptors (GPRs) were suggested to be activated by endocannabinoids, possibly regulating vasorelaxation. Here, we investigated whether GPR55 antag ...

Schattauer Gmbh-Verlag Medizin Naturwissenschaften2016

The Black cells phenotype is caused by a point mutation in the Drosophila pro-phenoloxidase 1 gene that triggers melanization and hematopoietic defects

Bruno Lemaitre, Maroun Bou Sleiman, Claudine Danielle Patricia Öngen, Olivier Binggeli

Melanization contributes to arthropod-specific innate immunity through deposition of melanin at wound sites or around parasites, with concomitant release of microbicidal reactive oxygen species. Melanization requires sequential activation of proteolytic en ...

Elsevier2015

Genetic, molecular and physiological basis of variation in Drosophila gut immunocompetence

Bruno Lemaitre, Bart Deplancke, Maroun Bou Sleiman, Andreas Massouras, Dani Osman

Gut immunocompetence involves immune, stress and regenerative processes. To investigate the determinants underlying inter-individual variation in gut immunocompetence, we perform enteric infection of 140 Drosophila lines with the entomopathogenic bacterium ...

Nature Publishing Group2015

Targeting pathways downstream of KRAS in lung adenocarcinoma

Oncogenic KRAS activation is responsible for the most common genetic subtype of lung cancer. Although many of the major downstream signaling pathways that KRAS engages have been defined, these discoveries have yet to translate into effective targeted thera ...

Future Medicine Ltd2014

Evaluation of uptake and transport of ultrasmall superparamagnetic iron oxide nanoparticles by human brain-derived endothelial cells

Heinrich Hofmann

Aim: Ultrasmall superparamagnetic iron oxide nanoparticles (USPIO-NPs) are under development for imaging and drug delivery; however, their interaction with human blood brain barrier models is not known. Materials & Methods: The uptake, reactive oxygen spec ...

2012

The role of sulfated metabolites in the wound response of siphonous green algae

The giant unicellular macroalgae exhibit an extraordinary wound repair mechanism. The rapid assimilation of cellular contents into an insoluble wound plug prevents detrimental cytoplasmic loss and limits the intrusion of extracellular components which coul ...

EPFL2010

Brief Bursts Self-Inhibit and Correlate the Pyramidal Network

Henry Markram, Rodrigo de Campos Perin, Gilad Silberberg

Inhibitory pathways are an essential component in the function of the neocortical microcircuitry. Despite the relatively small fraction of inhibitory neurons in the neocortex, these neurons are strongly activated due to their high connectivity rate and the ...

Public Library of Science2010