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Concept

Dépendance à Internet

Publications associées (4)

A preclinical model for identifying rats at risk of alcohol use disorder

Pierre Magistretti

Alcohol use is one of the world's leading causes of death and disease, although only a small proportion of individuals develop persistent alcohol use disorder (AUD). The identification of vulnerable individuals prior to their chronic intoxication remains o ...

Springer Nature2017

Isoform switching of steroid receptor co-activator-1 attenuates glucocorticoid-induced anxiogenic amygdala CRH expression

Maladaptive glucocorticoid effects contribute to stress-related psychopathology. The glucocorticoid receptor (GR) that mediates many of these effects uses multiple signaling pathways. We have tested the hypothesis that manipulation of downstream factors (' ...

Nature Publishing Group2016

Methyl Supplementation Attenuates Cocaine-Seeking Behaviors and Cocaine-Induced c-Fos Activation in a DNA Methylation-Dependent Manner

Fiona Hollis

Epigenetic mechanisms, such as histone modifications, regulate responsiveness to drugs of abuse, such as cocaine, but relatively little is known about the regulation of addictive-like behaviors by DNA methylation. To investigate the influence of DNA methyl ...

Soc Neuroscience2015

ADDICT: Advanced Instruction Chasing for Transactions

Anastasia Ailamaki, Pinar Tözün

Recent studies highlight that traditional transaction processing systems utilize the micro-architectural features of modern processors very poorly. L1 instruction cache and long-latency data misses dominate execution time. As a result, more than half of th ...

2014