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Publications associées (22)

Proton mobility in 2-substituted 1,3-dichlorobenzenes: "ortho" or "meta" metalation?

Rosario Scopelliti, Christophe Heiss

Nine 1,3-dichlorobenzene congeners were selected as model compds. to assess the relative rates of proton abstraction from 4- and 5-positions ("ortho" vs. "meta" metalation). Using lithium 2,2,6,6-tetramethylpiperidide as the basic reagent, the chlorine-adj ...

2006

The structural proliferation of fluorinated building blocks by regiochemically exhaustive functionalizations

Organofluorine compds. do not grow on trees. They have to be prepd. by introducing the halogen into the carbon backbone at a suitable stage of the synthesis sequence. From a logistic point of view, the key question is, when exactly. For example, if one dea ...

2005