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Concept

Insulin-like growth factor

Publications associées (26)

Extracellular Matrix-Inspired Growth Factor Delivery Systems for Skin Wound Healing

Jeffrey Alan Hubbell, Priscilla Suhasna Maithili Briquez

Significance: Growth factors are very promising molecules for the treatment of skin wounds. However, their translation to clinical use has been seriously limited, facing issues related to safety and cost-effectiveness. These problems may derive from the fa ...

Mary Ann Liebert, Inc2015

Defining the role of common variation in the genomic and biological architecture of adult human height

Paul Jack Mc Laren, Jiancheng Yang, Murielle Bochud, Jian Yang

Using genome-wide data from 253,288 individuals, we identified 697 variants at genome-wide significance that together explained one-fifth of the heritability for adult height. By testing different numbers of variants in independent studies, we show that th ...

Nature Publishing Group2014

Impact of environmental estrogens on fish considering the diversity of estrogen signaling

Research on endocrine disruption in fish has been dominated by studies on estrogen-active compounds which act as mimics of the natural estrogen, 17 beta-estradiol (E2), and generally exert their biological actions by binding to and activation of estrogen r ...

Elsevier2013

Specific Silencing of the REST Target Genes in Insulin-Secreting Cells Uncovers Their Participation in Beta Cell Survival

Emilie Gesina

The absence of the transcriptional repressor RE-1 Silencing Transcription Factor (REST) in insulin-secreting beta cells is a major cue for the specific expression of a large number of genes. These REST target genes were largely ascribed to a function of ne ...

Public Library of Science2012

Engineered insulin-like growth factor-1 for improved smooth muscle regeneration

Jeffrey Alan Hubbell, Peter Frey

Insulin-like growth factor-1 (IGF-1) has been shown to induce potent mitogenic responses in various cell types, yet its sustained local delivery is still an underdeveloped domain in the clinic. We report here an engineered IGF-1 that facilitates extended l ...

2012

Biofunctional Scaffold Design for Soft Tissue Regeneration

Fibrin has long been used clinically for hemostasis and sealing and has been extensively characterized as a biomaterial. Yet, in terms of harnessing its potential for use in tissue regeneration, there remains a wide gap between in vitro experimentation and ...

EPFL2011