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Concept

Thermothérapie (cancérologie)

Publications associées (13)

Magnetic hyperthermia with epsilon-Fe(2)O(3)nanoparticles

Débora Bonvin

Biocompatibility restrictions have limited the use of magnetic nanoparticles for magnetic hyperthermia therapy to iron oxides, namely magnetite (Fe3O4) and maghemite (gamma-Fe2O3). However, there is yet another magnetic iron oxide phase that has not been c ...

2020

Gap-Plasmon-Enhanced High-Spatial-Resolution Imaging by Photothermal-Induced Resonance in the Visible Range

Giovanni Dietler, Serguei Sekatski, Jiangtao Zhou, Anton Smirnov

Chemical characterization at the nanoscale is of significant importance for many applications in physics, analytical chemistry, material science, and biology. Despite the intensive studies in the infrared range, high-spatial resolution and high-sensitivity ...

AMER CHEMICAL SOC2019

Controlling structural and magnetic properties of IONPs by aqueous synthesis for improved hyperthermia

Heinrich Hofmann, Alla Arakcheeva, Marijana Mionic Ebersold, Débora Bonvin

Iron oxide nanoparticles (IONPs) were synthesized by a novel aqueous synthesis route which combines co-precipitation (CP) and hydrothermal (HT) treatment, termed CP + HT, and compared with IONPs obtained by the standard CP method. Properties of both types ...

2017

Stepwise growth of gold coated cancer targeting carbon nanotubes for the precise delivery of doxorubicin combined with photothermal therapy

Paul Joseph Dyson, Zhaofu Fei

Combining doxorubicin with thermal therapy in the clinic has led to startling results in the treatment of problematic cancers. Here, we describe a multimo dal multi-walled carbon nanotube material that combines tumor targeting, doxorubicin delivery, and ph ...

Royal Society of Chemistry2017

Combination of ruthenium(II)-arene complex [Ru(eta(6)-p-cymene)Cl-2(pta)] (RAPTA-C) and the epidermal growth factor receptor inhibitor erlotinib results in efficient angiostatic and antitumor activity

Paul Joseph Dyson, Patrycja Nowak-Sliwinska, Andrea Brett Gasser

Ruthenium-based compounds show strong potential as anti-cancer drugs and are being investigated as alternatives to other well-established metal-based chemotherapeutics. The organometallic compound [Ru(eta(6)-p-cymene) Cl-2(pta)], where pta = 1,3,5-triaza-7 ...

Nature Research2017

Iron oxide nanoparticles for diagnosis and therapy of lymph node metastases

Débora Bonvin

This thesis presents the synthesis, coating and characterization of iron oxide nanoparticles (IONPs) with properties especially designed for the ultimate simultaneous MRI detection and hyperthermia treatment of lymph node metastases, a combination called t ...

EPFL2017

Folic acid on iron oxide nanoparticles: platform with high potential for simultaneous targeting, MRI detection and hyperthermia treatment of lymph node metastases of prostate cancer

Heinrich Hofmann, Josefina Adriana Maria Bastiaansen, Marijana Mionic Ebersold, Débora Bonvin

The overexpression of the folate receptor in most cancers has been widely exploited to specifically deliver folic acid (FA) coupled nanomedicines to tumors. However, complex coupling chemistry is often used to bind FA to the nanoparticles. Furthermore, ver ...

Royal Society of Chemistry2017

Magnetic nanoparticle-induced hyperthermia with appropriate payloads: Paul Ehrlich's "magic (nano)bullet" for cancer theranostics?

Heinrich Hofmann

Effective multimodal cancer management requires the optimal integration of diagnostic and therapeutic modalities. Radiation therapy, chemotherapy and immunotherapy, alone or in combination, are integral parts of various cancer treatment protocols. Hyperthe ...

Elsevier2016

Realistic Modeling of 3D Plasmonic Systems : A Surface Integral Equation Approach

Andreas Kern

Interest in plasmonic nanostructures has recently multiplied due to their extraordinary optical properties. When resonantly excited, these tiny metallic systems exhibit a strong and localized optical field enhancement. Applications exploiting this effect e ...

EPFL2011

Use of Perfluorinated Phosphines to Provide Thermomorphic Anticancer Complexes for Heat-Based Tumor Targeting

Paul Joseph Dyson, Rosario Scopelliti, Anna Katherine Renfrew

[Ru(η6-arene)(pta)(PR3)Cl]BF4 (arene = p-cymene or 4-phenyl-2-butanol; pta = 1,3,5-triaza-7-phosphatricyclo[3.3.1.1]decane, PR3 = PPh2(p-C6H4C2H4C8F17), PPh(p-C6H4C2H4C8F17)2, P(p-C6H4C2H4C6F13)3, PPh3 or P(p-C6H4F)3) were prepd. and characterized by spect ...

2010

The in vivo performance of magnetic particle-loaded injectable, in situ gelling, carriers for the delivery of local hyperthermia

Heinrich Hofmann, Alke Fink, Antonin Faes

In situ forming implants are attractive for minimally invasive localized therapies such as aneurysm embolization. As for the superparamagnetic iron oxide nanoparticles (SPIONs), their deposition/injection in a target tissue area allows magnetically induced ...

2010

Local moderate magnetically induced hyperthermia using an implant formed in situ in a mouse tumor model

Heinrich Hofmann, Alke Fink

Purpose: We investigate a new heat delivery technique for the local treatment of solid tumors. The technique involves injecting a formulation that solidifies to form an implant in situ. This implant entraps superparamagnetic iron oxide nanoparticles (SPION ...

Taylor & Francis2009

Inverse problems in acoustic tomography : theory and applications

Ivana Jovanovic

Acoustic tomography aims at recovering the unknown parameters that describe a field of interest by studying the physical characteristics of sound propagating through the considered field. The tomographic approach is appealing in that it is non-invasive and ...

EPFL2008