Concept

Bone remodeling

Publications associées (28)

Growth of osteosarcoma cells in a three-dimensional bone-like matrix alters their susceptibility to adeno-associated virus

Osteosarcoma cells U2OS are partially susceptible to adeno-associated virus (AAV)-2 infection, allowing efficient synthesis of Rep proteins and, in a low percentage of cells, capsid production. It is not clear if this partial susceptibility to infection is ...

Soc General Microbiology2014

Integration of mechanotransduction concepts in bone tissue engineering

Dominique Pioletti

Mechanical stimulus has been identified for a long time as a key player in the adaptation of the musculo-skeletal tissues to their function. Mechanical loading is then an intrinsic variable to be considered when new developments are proposed in bone tissue ...

Taylor & Francis2013

The Mechanical Environment Modulates Intracellular Calcium Oscillation Activities of Myofibroblasts

Boris Hinz, Adriano Garonna, Lysianne Follonier Castella

Myofibroblast contraction is fundamental in the excessive tissue remodeling that is characteristic of fibrotic tissue contractures. Tissue remodeling during development of fibrosis leads to gradually increasing stiffness of the extracellular matrix. We pro ...

Public Library Science2013

Improving the osteogenic potential of BMP-2 with hyaluronic acid hydrogel modified with integrin-specific fibronectin fragment

Jeffrey Alan Hubbell

While human bone morphogenetic protein-2 (rhBMP-2) is a promising growth factor for bone regeneration, its clinical efficacy has recently shown to be below expectation. In order to improve the clinical translation of rhBMP-2, there exists strong motivation ...

Elsevier2013

Plasticization of polylactide foams for tissue engineering

Jan-Anders Edvin Maansson, John Christopher Plummer, Pierre-Etienne Bourban, Matthieu Cuénoud

Supercritical CO2 foaming of amorphous and semicrystalline polylactides plasticized by blending with 20 wt% polyethylene glycol has been investigated as a means of producing low-stiffness bioresorbable scaffolds for tissue engineering. For a given set of f ...

SAGE Publications2012

Prediction of spatio-temporal bone formation in scaffold by diffusion equation

Dominique Pioletti, Alireza Roshan Ghias, Arne Christian Vogel

Developing a successful bone tissue engineering strategy entails translation of experimental findings to clinical needs. A major leap forward towards this goal is developing a quantitative tool to predict spatial and temporal bone formation in scaffold. We ...

2011

In vivo loading increases mechanical properties of scaffold by affecting bone formation and bone resorption rates

Dominique Pioletti, Alireza Roshan Ghias

A successful bone tissue engineering strategy entails producing bone-scaffold construct with adequate mechanical properties. Apart from the mechanical properties of the scaffold itself, the forming bone inside the scaffold also adds to the strength of the ...

2011

Biomechanical Aspects of Osteogenesis in Load-Bearing Tissue Engineering Scaffolds

Alireza Roshan Ghias

There is increasing evidence that mechanical stimulation affects the fate of tissue engineering scaffolds. In clinical situations, it is critical to accelerate bone formation inside the scaffold to reduce the recovery time and increase the chance of succes ...

EPFL2011