Concept

Eradication of infectious diseases

Publications associées (29)

Toward Nanotechnology-Enabled Approaches against the COVID-19 Pandemic

The COVID-19 outbreak has fueled a global demand for effective diagnosis and treatment as well as mitigation of the spread of infection, all through large-scale approaches such as specific alternative antiviral methods and classical disinfection protocols. ...

AMER CHEMICAL SOC2020

Regulation of cGAS- and RLR-mediated immunity to nucleic acids

Andrea Ablasser

Pathogen-derived nucleic acids are crucial signals for innate immunity. Despite the structural similarity between those and host nucleic acids, mammalian cells have been able to evolve powerful innate immune signaling pathways that originate from the detec ...

NATURE PUBLISHING GROUP2020

The FDA-Approved Drug Nelfinavir Inhibits Lytic Cell-Free but Not Cell-Associated Nonlytic Transmission of Human Adenovirus

Gerardo Turcatti, Fabien Kuttler

Adenoviruses (AdVs) are prevalent and give rise to chronic and re-current disease. Human AdV (HAdV) species B and C, such as HAdV-C2, -C5, and-B14, cause respiratory disease and constitute a health threat for immunocom-promised individuals. HAdV-Cs are wel ...

2020

Modelled effects of prawn aquaculture on poverty alleviation and schistosomiasis control

Andrea Rinaldo, Lorenzo Mari, Francisco Javier Perez Saez

Recent evidence suggests that snail predators may aid efforts to control the human parasitic disease schistosomiasis by eating aquatic snail species that serve as intermediate hosts of the parasite. Here, potential synergies between schistosomiasis control ...

NATURE PUBLISHING GROUP2019

Gene drives for schistosomiasis transmission control

Francisco Javier Perez Saez

Schistosomiasis is one of the most important and widespread neglected tropical diseases (NTD), with over 200 million people infected in more than 70 countries; the disease has nearly 800 million people at risk in endemic areas. Although mass drug administr ...

2019

Boosting subdominant neutralizing antibody responses with a computationally designed epitope-focused immunogen

Bruno Emanuel Ferreira De Sousa Correia, Jaume Bonet Martinez, Pablo Gainza Cirauqui, Fabian Sesterhenn, Stéphane Rosset, Che Yang, Patricia Corthésy Henrioud, Sabrina Susan Vollers

Throughout the last several decades, vaccination has been key to prevent and eradicate infectious diseases. However, many pathogens (e.g., respiratory syncytial virus [RSV], influenza, dengue, and others) have resisted vaccine development efforts, largely ...

2019

Assessing the interplay between human mobility and mosquito borne diseases in urban environments

Emanuele Massaro

Urbanization drives the epidemiology of infectious diseases to many threats and new challenges. In this research, we study the interplay between human mobility and dengue outbreaks in the complex urban environment of the city-state of Singapore. We integra ...

Springer Nature2019

Space and time predictions of schistosomiasis snail host population dynamics across hydrologic regimes in Burkina Faso

Andrea Rinaldo, Francisco Javier Perez Saez, Theophile Mande

The ecology of the aquatic snails that serve as obligatory intermediate hosts of human schistosomiasis is driven by climatic and hydrological factors which result in specific spatial patterns of occurrence and abundance. These patterns in turn affect, join ...

2019

Intestinal helminths modulate the gut microbiome

Alexis Rapin

Intestinal parasitic worms (commonly named intestinal helminths) affect close to one quarter of the world population and cause major losses for the livestock industry. These parasites establish chronic infections by modulation the immunity of their host. T ...

EPFL2018