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Concept

Histoire de la médecine

Publications associées (5)

Sporadic type VI secretion in seventh pandemic Vibrio cholerae

Melanie Blokesch, Sandrine Stutzmann, Natalia Carolina Drebes Dorr, Nicolas René Chiaruttini, Loriane Bader, Sandrine Natacha Isaac, Lisa Christina Metzger, Alexis Joseph Proutière

Vibrio cholerae is a pathogen that causes disease in millions of people every year by colonizing the small intestine and then secreting the potent cholera toxin. How the pathogen overcomes the colonization barrier created by the host’s natural microbiota i ...

2023

Two defence systems eliminate plasmids from seventh pandemic Vibrio cholerae

Melanie Blokesch, David William Adams, Milena Jadwiga Jaskolska

Horizontal gene transfer can trigger rapid shifts in bacterial evolution. Driven by a variety of mobile genetic elements—in particular bacteriophages and plasmids—the ability to share genes within and across species underpins the exceptional adaptability o ...

2022

Genetics of human susceptibility to active and latent tuberculosis: present knowledge and future perspectives

Jacques Fellay, Nimisha Chaturvedi

Tuberculosis is an ancient human disease, estimated to have originated and evolved over thousands of years alongside modern human populations. Despite considerable advances in disease control, tuberculosis remains one of the world's deadliest communicable ...

2018

Identification of Siglec-1 null individuals infected with HIV-1

Jacques Fellay, Paul Jack Mc Laren

Siglec-1/CD169 is a myeloid-cell surface receptor critical for HIV-1 capture and infection of bystander target cells. To dissect the role of SIGLEC1 in natura, we scan a large population genetic database and identify a loss-of-function variant (Glu88Ter) t ...

Nature Publishing Group2016

Coûts de la regulation des industries des réseaux: Enseignements du réseau postal

Matthias Finger, Martin Maegli

La régulation joue un rôle important dans la mise en œuvre de la libéralisation des industries de réseau. Si elle vise à favoriser une certaine prospérité de l’économie et de la société, cette intervention de l’Etat présente certaines limites. Les procédur ...

2009