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Concept

Élution

Publications associées (9)

On-chip mesoporous functionalized magnetic microspheres for protein sequencing by extended bottom-up mass spectrometry

Hubert Girault, Yury Tsybin, Liang Qiao, Natalia Gasilova, Kristina Srzentic

Limited amount and extreme concentration variability of proteomic-related samples require efficient analyte preconcentration and purification prior to the mass spectrometry (MS)-based analysis. Preferably, these steps should be coupled on-line with chosen ...

American Chemical Society2016

Superhydrophobic bull's-eye for surface-enhanced Raman scattering

Demetri Psaltis, Wuzhou Song

We present a micro-patterned silicon structure that enables the preparation of a substrate for surface-enhanced Raman scattering (SERS) and pre-concentration of the analyte molecules. The structure is designed to produce a hydrophobicity gradient. As a res ...

Royal Society of Chemistry2014

Scanning Electrochemical Microscopy and Finite Element Modeling of Structural and Transport Properties of Electrochemical Systems

Dmitry Momotenko

Understanding the fundamental properties of electrochemical systems, especially at the microscopic level, requires advanced tools combining electrochemical microscopy and scanning probe techniques with mathematical modeling for the quantification of the ph ...

EPFL2013

On the utility of predictive chromatography to complement mass spectrometry based intact protein identification

Yury Tsybin, Hisham Ben Hamidane

The amino acid sequence determines the individual protein three-dimensional structure and its functioning in an organism. Therefore, "reading" a protein sequence and determining its changes due to mutations or post-translational modifications is one of the ...

Springer-Verlag2012

Influence of the Adsorbent Material in the Performances of a Micro Gas Preconcentrator

Nico de Rooij, Danick Briand, El Hadji Malick Camara

This paper presents the evaluation of different adsorbents for the improvement of the performances of a gas preconcentrator by targeting the adsorption of a large range of volatiles organics compounds (VOCs) The objectives of this work are to find the adeq ...

2009

Continuous sampling and analysis by on-chip liquid/solid chromatography

Philippe Renaud, Mario Schlund

This paper describes a lab-on-a-chip device for continuous liquid/solid chromatography measurements. Chromatographic separations of phenolic test solutions as well as of vitamins are illustrating the ability and versatility of the system. The dependence of ...

Elsevier2007

The affinity precipitation for the isolation of biomolecules

Gisela Stocker Majd

Product isolation increasingly becomes a major bottleneck in molecular biotechnology. This is especially the case for the sensitive proteineous substances (recombinant proteins, antibodies) and lately also DNA, usually produced in low concentration. The cu ...

EPFL2007

Numerical Simulation of Two-Phase Partition Chromatography in Microchannels for Moderated Log P Measurements

Hubert Girault, Pierre-Alain Carrupt

A finite element simulation has been used in order to study the partition chromatography process of one species between an aqueous mobile phase and an organic stationary phase located at the bottom of a rectangular microchannel. The transient model incorpo ...

Elsevier2005

Experimental and numerical modelling comparative study of ion-exchange chromatography

Magdalena Jozwik

Chromatography is increasingly being used for large-scale preparative separation of precious biological components such as recombinant proteins and DNA. Several kinds of mathematical models are used to describe the liquid chromatography process. The aim of ...

EPFL2004