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Concept

Audiométrie

Publications associées (5)

Delivery of CRISPR/Cas9 using AAV-PHP.B in the inner ear leads to allele-specific inactivation of the mutated Tmc1 allele and protects auditory function in Beethoven mice

Bernard Schneider, Paola Andrea Solanes Vega, Sofia Carmen Suzanne Spataro

Hearing Loss (HL) is the most prevalent sensorineural disorder, affecting 360 million people worldwide. As genetic causes lead to 50% of pre-lingual deafness, gene therapy is considered as a potential therapeutic strategy. Mutations in the TMC1 gene are li ...

MARY ANN LIEBERT, INC2019

A 3D Microscaffold Cochlear Electrode Array for Steroid Elution

Jürgen Brugger, Joo Yeon Kim, Jongmoon Jang

In cochlear implants, the electrode insertion trauma during surgery can cause damage residual hearing. Preserving the residual hearing is an important challenge and the localized administration of drugs, such as steroids, is one of the most promising ways, ...

2019

Circadian Regulation of Cochlear Sensitivity to Noise by Circulating Glucocorticoids

Benjamin Dieter Weger, Frédéric Bruno Martin Gachon

The cochlea possesses a robust circadian clock machinery that regulates auditory function. How the cochlear clock is influenced by the circadian system remains unknown. Here, we show that cochlear rhythms are system driven and require local Bmal1 as well a ...

2019

Objective evaluation of static beamforming on the quality of speech in noise

Hervé Lissek, Gilles André Courtois, Vincent Pierre Olivier Grimaldi

Beamforming is commonly used in devices such as in hearing instruments (HI) with a view to reducing noise. It consists in focusing on audio signals arising from a prescribed steering direction while suppressing those coming from other directions. The effic ...

European Acoustics Association2018

Human audiometric thresholds do not predict specific cellular damage in the inner ear

Demetri Psaltis

Introduction: As otology enters the field of gene therapy and human studies commence, the question arises whether audiograms - the current gold standard for the evaluation of hearing function - can consistently predict cellular damage within the human inne ...

Elsevier2016