Concept

Modelling biological systems

Publications associées (30)

Computational methods and modeling of cellular function for the optimization of protein production and the study of cellular disease states

Systems biology is a multidisciplinary field that weaves together all the basic sciences through the use of computational and bioinformatics tools, to provide a more integrative view of the complex molecular interactions taking place within and among cells ...

EPFL2017

Profiling of Single-Cell Transcriptomes

Bart Deplancke, Vincent Roland Julien Gardeux, Wanze Chen, Antonio Carlos Alves Meireles Filho

Complex biological systems are composed of multiple cell types whose transcriptional activity can vary due to differences in cell state, environmental stimulation or intrinsic programs. Conventional bulk analysis methods capture the average transcriptional ...

2017

An Insect Eye Inspired Miniaturized Multi-Camera System for Endoscopic Imaging

Yusuf Leblebici, Ömer Cogal

In thiswork,we present aminiaturized high definition vision system inspired by insect eyes, with a distributed illumination method, which can work in dark environments for proximity imaging applications such as endoscopy. Our approach is based on modeling ...

Ieee-Inst Electrical Electronics Engineers Inc2017

Integration of Metabolic, Regulatory and Signaling Networks Towards Analysis of Perturbation and Dynamic Responses

Vassily Hatzimanikatis, Meriç Ataman, Anush Chiappino-Pepe, Vikash Kumar Pandey

The expanding generation of dynamic biological data requires approaches that integrate and analyze information from different types of cellular processes –metabolism, regulation, and signaling–, and ultimately increase our insights into the cell behavior u ...

2017

Principles of Systems Biology, No. 11

Vassily Hatzimanikatis, Noushin Hadadi, Jasmin Maria Hafner

This month: AI that learns patterns and facts, new protein-RNA and protein-protein relationships, engineering signaling and metabolism, and more variants of Cas9. ...

Cell Press2016

Extension of least squares spectral resolution algorithm to high-resolution lipidomics data

Adrian Schmid

Lipidomics, which focuses on the global study of molecular lipids in biological systems, has been driven tremendously by technical advances in mass spectrometry (MS) instrumentation, particularly high-resolution MS. This requires powerful computational too ...

Elsevier2016

Quantifying electron transfer reactions in biological systems: what interactions play the major role?

Various biological processes involve the conversion of energy into forms that are usable for chemical transformations and are quantum mechanical in nature. Such processes involve light absorption, excited electronic states formation, excitation energy tran ...

Nature Publishing Group2015

Lipid Builder: A Framework To Build Realistic Models for Biological Membranes

Matteo Dal Peraro, Thomas Lemmin, Giorgio Elikem Tamo, Christophe Bovigny, Nicolas Grégoire Maïno

The physical and chemical characterization of biological membranes is of fundamental importance for understanding the functional role of lipid bilayers in shaping cells and organelles, steering vesicle trafficking and promoting membrane-protein signaling. ...

Amer Chemical Soc2015

From cardiac tissue engineering to heart-on-a-chip: beating challenges

Francesco Piraino

The heart is one of the most vital organs in the human body, which actively pumps the blood through the vascular network to supply nutrients to as well as to extract wastes from all other organs, maintaining the homeostasis of the biological system. Over t ...

Iop Publishing Ltd2015

Accurate and Inexpensive Prediction of the Color Optical Properties of Anthocyanins in Solution

Iurii Timrov

The simulation of the color optical properties of molecular dyes in liquid solution requires the calculation of time evolution of the solute absorption spectra fluctuating in the solvent at finite temperature. Time-averaged spectra can be directly evaluate ...

Amer Chemical Soc2015