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Concept

Histologie

Publications associées (30)

Cell-based quantification of biomarkers from an ultra-fast microfluidic immunofluorescent staining: application to breast cancer cell lines

Martinus Adela Maria Gijs, Daniel Migliozzi, Huu Tuan Nguyen

Immunohistochemistry (IHC) is one of the main techniques currently used in the clinics for biomarker characterization. It consists in colorimetric labeling with specific antibodies followed by microscopy analysis. The results are then used for diagnosis an ...

SPIE-INT SOC OPTICAL ENGINEERING2018

Microfluidics-based immunofluorescence for fast staining of ALK in lung adenocarcinoma

Diego Gabriel Dupouy, Benjamin Pelz, Saska Brajkovic

BackgroundAnaplastic lymphoma kinase (ALK) is a key oncogenic driver in lung adenocarcinoma patients and its fusion proteins are routinely assessed. The microfluidic tissue processor (MTP) device is based on a chip-confined low-volume technology allowing f ...

BMC2018

The role of Snail in non-small cell lung cancer

Svenja Johanna Groeneveld

The epithelial-to-mesenchymal transition (EMT) is a developmental program frequently reactivated in cancer. It plays an important role in several aspects of tumor progression, particularly in the acquisition of invasive capacities facilitating metastasis. ...

EPFL2018

Tomographic imaging with harmonic holography in tissues of known refractive index distribution

Demetri Psaltis, Ye Pu

High-resolution imaging in thick biological tissues beyond a few transport mean free path of photons remains a formidable challenge to modern science and technology. Recent advancements in optical tomography have enabled the reconstruction of the three-dim ...

SPIE-INT SOC OPTICAL ENGINEERING2018

Comparison of hock- and footpad-injection as a prostate adenocarcinoma model in rats

BackgroundObjective of this study is a feasibility-test comparing hock- and footpad-injection in rats with inoculated MatLyLu - adenocarcinoma tumor model. This study compares the development of an adenocarcinoma model (MatLyLu) in 12 Copenhagen rats. Two ...

2018

Optical cuff for optogenetic control of the peripheral nervous system

Stéphanie Lacour, Grégoire Courtine, Léonie Asboth, Frédéric Pierre Gérald Michoud

Objective. Nerves in the peripheral nervous system (PNS) contain axons with specific motor, somatosensory and autonomic functions. Optogenetics offers an efficient approach to selectively activate axons within the nerve. However, the heterogeneous nature o ...

2018

Assessing feasibility and reproducibility of a bundle-specific framework on in vivo axon diameter estimates at 300mT/m

Jean-Philippe Thiran, Alessandro Daducci, Gabriel Girard, David Paul Roger Romascano, Maxime Descoteaux, Muhamed Barakovic, Jonathan Rafael Patino Lopez, Giorgio Innocenti

In vivo quantitative estimation of axon diameter in the white matter could bring new tools to study the structural and functional architecture of the brain. Recently, the feasibility of axon diameter estimation with diffusion-weighted MRI (DW-MRI) has been ...

2018

Structural and functional brain imaging using extended-focus optical coherence tomography and microscopy

Paul James Marchand

Neuroimaging techniques aim at revealing the anatomy and functional organisation of cerebral structures. Over the past decades, functional magnetic resonance imaging (fMRI) has revolutionized our understanding of human cerebral physiology through its abili ...

EPFL2018

Improvement of breast cancer diagnosis through microfluidics

Huu Tuan Nguyen

In breast cancer, 15-20% of cases are reported with overexpression of human epidermal growth factor receptor 2 (HER2) that causes rapid cancer progression and poor prognosis. Fortunately, HER2-targeted therapy using specific antibodies such as Trastuzumab ...

EPFL2018

Optical projection tomography for rapid whole mouse brain imaging

Dimitri Nestor Alice Van De Ville, Theo Lasser, Jérôme Extermann, Paul James Marchand, Antonio Lopez, Miguel Sison, David Nguyen, Arielle Louise Planchette, Jessica Sordet, Marcin Antoni Sylwestrzak

In recent years, three-dimensional mesoscopic imaging has gained significant importance in life sciences for fundamental studies at the whole-organ level. In this manuscript, we present an optical projection tomography (OPT) method designed for imaging of ...

Optical Soc Amer2017