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Concept

Selective androgen receptor modulator

Publications associées (26)

The FDA-approved natural product dihydroergocristine reduces the production of the Alzheimer's disease amyloid-beta peptides

Patrick Fraering

Known gamma-secretase inhibitors or modulators display an undesirable pharmacokinetic profile and toxicity and have therefore not been successful in clinical trials for Alzheimer's disease (AD). So far, no compounds from natural products have been identifi ...

Nature Publishing Group2015

No Scope for Social Modulation of Steroid Levels in a Year-Round Territorial Damselfish

Both latitude and mating system have been proposed to shape relationships between steroid hormone levels and social behavior. Recently it has been postulated that species with long lasting non-seasonal territorial behavior have low androgen responsiveness. ...

Wiley-Blackwell2015

Intra- and interspecific social challenges modulate the levels of an androgen precursor in a seasonally territorial tropical damselfish

Studies on different vertebrate groups have provided evidence that androgen levels in males increase after competitive social interactions during the breeding season, as postulated by the Challenge Hypothesis. However, social modulation of androgen levels ...

Academic Press Inc Elsevier Science2015

Potential of Cycloaddition Reactions To Generate Cytotoxic Metal Drugs In Vitro

Paul Joseph Dyson, Sviatlana Siankevich, Benjamin Samuel Murray

Severe general toxicity issues blight many chemotherapeutics utilized in the treatment of cancers, resulting in the need for more selective drugs able to exert their biological activity at only the required location(s). Toward this aim, we report the devel ...

Amer Chemical Soc2014

Functional analysis of NR2E3 in retinal degenerations

The vertebrate retina is a model system of the development of the central nervous system. Because of its rapid development and the availability of many molecular tools the zebrafish is an established model of retinal development. Development and maintenanc ...

EPFL2014

The Corepressor NCoR1 Antagonizes PGC-1α and Estrogen-Related Receptor α in the Regulation of Skeletal Muscle Function and Oxidative Metabolism

Johan Auwerx

Skeletal muscle exhibits a high plasticity and accordingly can quickly adapt to different physiological and pathological stimuli by changing its phenotype largely through diverse epigenetic mechanisms. The nuclear receptor corepressor 1 (NCoR1) has the abi ...

Amer Soc Microbiology2012