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Concept

Hypoxie

Publications associées (29)

AltitudeOmics: Spontaneous Baroreflex Sensitivity During Acclimatization to 5,260 m: A Comparison of Methods

Jean-Marc Vesin, Sasan Yazdani

Introduction Baroreflex sensitivity (BRS) is essential to ensure rapid adjustment to variations in blood pressure (BP). Spontaneous baroreflex function can be assessed using continuous recordings of blood pressure. The goal of this study was to compare fou ...

2019

Physiological Responses in Humans Acutely Exposed to High Altitude (3480 m): Minute Ventilation and Oxygenation Are Predictive for the Development of Acute Mountain Sickness

Johannes Burtscher

Burtscher, Martin, Michael Philadelphy, Hannes Gatterer, Johannes Burtscher, Martin Faulhaber, Werner Nachbauer, and Rudolf Likar. Physiological responses in humans acutely exposed to high altitude (3480 m): Minute ventilation and oxygenation are predictiv ...

MARY ANN LIEBERT, INC2019

Multispectral Near-Infrared Optical Tomography for Cancer Hypoxia Study in Mice

Matthias Wolf, Scott Anthony Lindner

Oxygenation of a tumor is one of the most important predictive factors: hypoxia is associated with aggressive tumors and substantially lower survival rate. Despite this high relevance of tumor oxygenation, there is currently no bedside technique available ...

SPRINGER INTERNATIONAL PUBLISHING AG2018

NOS2-deficient mice with hypoxic necrotizing lung lesions predict outcomes of tuberculosis chemotherapy in humans

Stewart Cole

During active TB in humans a spectrum of pulmonary granulomas with central necrosis and hypoxia exists. BALB/c mice, predominantly used in TB drug development, do not reproduce this complex pathology thereby inaccurately predicting clinical outcome. We fou ...

Nature Research2017

Negligible interaction of [Ru(Phen) 3 ] 2+ with human serum albumin makes it promising for a reliable in vivo assessment of the tissue oxygenation

Georges Wagnières, Veronika Huntosova

The interaction between a ruthenium - based water soluble oxygen probe ([Ru(Phen)3]2+, phen - phenanthroline) and human serum albumin (HSA) was investigated with the aim of describing the influence of HSA on the [Ru(Phen)3]2+ luminescence properties. Nowad ...

Elsevier2017

In vivo measurement of the tissue oxygenation by time-resolved luminescence spectroscopy of protoporphyrin IX: Strategies to minimize artefacts associated with photoproducts

Georges Wagnières, Veronika Huntosova, Emmanuel Louis Arthur Gerelli

The determination of the oxygen partial pressure (pO(2)) in real time in living biological tissues is of high interest for numerous therapeutics, including photodynamic therapy (PDT) and radiotherapy. The minimally invasive and real-time measurement of the ...

Spie-Int Soc Optical Engineering2017

Fingolimod protects against neonatal white matter damage and long-term cognitive deficits caused by hyperoxia

Yohan Van de Looij

Cerebral white matter injury is a leading cause of adverse neurodevelopmental outcome in prematurely born infants involving cognitive deficits in later life. Despite increasing knowledge about the pathophysiology of perinatal brain injury, therapeutic opti ...

Elsevier2016

JNK Inhibition Reduced Retinal Ganglion Cell Death after Ischemia/Reperfusion In Vivo and after Hypoxia In Vitro

Tatiana Favez

Mitogen-activated protein kinases (MAPKs) are key regulators that have been linked to cell survival and death. Among the main classes of MAPKs, c-jun N-terminal kinase (JNK) has been shown to mediate cell stress responses associated with apoptosis. In Vitr ...

Springer Int Publishing Ag2016

Lactoferrin during lactation reduces lipopolysaccharide-induced brain injury

Yohan Van de Looij

Lactoferrin (Lf), component of maternal milk, has antioxidant, anti-inflammatory and antimicrobial properties. Neuroprotective effects of Lf on the immature brain have been recently shown in rodent models of intrauterine growth restriction and cerebral hyp ...

Wiley-Blackwell2016