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Concept

Synthèse en phase solide

Publications associées (31)

Methods for the generation of large combinatorial macrocycle libraries

Sevan Mleh Habeshian

Macrocycles are an attractive class of molecules due to their good binding properties and yet rather small size that allows, in many cases, crossing membranes to reach intracellular targets. In comparison to classical small molecule drugs, macrocycles are ...

EPFL2021

Colloidal Nanocrystals as Precursors and Intermediates in Solid State Reactions for Multinary Oxide Nanomaterials

Raffaella Buonsanti, Anna Loiudice, Valeria Mantella

Polyelemental compounds with dimensions in the nanosized regime are desirable in a large variety of applications, yet their synthesis remains a general challenge in chemistry. One of the major bottlenecks to obtaining multinary systems is the complexity of ...

American Chemical Society2021

Exploring Synthetic Strategies for Nanocrystal/Reticular Framework Hybrids and Their Potential as CO2 Reduction Electrocatalysts

Yannick Thomas Guntern

The electrochemical CO2 reduction reaction (CO2RR) into valuable chemicals has the potential to realize a carbon-neutral energy cycle. Developing catalysts that can achieve high selectivity towards one of the possible reduction products is one of the bigge ...

EPFL2021

Edge Disorder in Bottom-Up Zigzag Graphene Nanoribbons: Implications for Magnetism and Quantum Electronic Transport

Oleg Yazyev, Michele Pizzochero, Kristians Cernevics

We unveil the nature of the structural disorder in bottom-up zigzag graphene nanoribbons along with its effect on the magnetism and electronic transport on the basis of scanning probe microscopies and first-principles calculations. We find that edge-missin ...

AMER CHEMICAL SOC2021

Advancing computational and data-driven methods for the design and discovery of nanoporous materials

Seyedmohamad Moosavi

Metal-organic framework (MOFs) and related nanoporous materials have emerged as promising candidates for a variety of applications, such as gas separation and storage, catalysis, sensing, etc. Their building block structure allows us to generate a huge num ...

EPFL2020

Two-Step Synthesis of Linear and Bent Dicarboxylic Acid Metalloligands with Lengths of up to 3 nm

Rosario Scopelliti, Kay Severin, Farzaneh Fadaei Tirani, Suzanne Maria Jansze, Ophélie Marie Planes

Nanometer-sized polycarboxylate ligands are interesting building blocks for metallasupramolecular chemistry, but access to these compounds is often limited by complicated synthetic pathways. Here, we describe a simple two-step protocol, which allows prepar ...

2020

A Short Synthesis of the 2-Bromo-N,9-dimethyl-6,7,8,9-tetrahydro-5H-pyrido[2,3-b]indol-6-amine Building Block

Andrea Pfeifer

A concise synthesis of pharmaceutically useful (R)-tert-butyl N-(2-bromo-9-methyl-6,7,8,9-tetrahydro-5H-pyrido [2,3-b ] indol-6-yl) -N-methylcarbamate building block 11 is described. The racemic intermediate 17 was prepared in a single step from 2-bromo-6- ...

AMER CHEMICAL SOC2019

Synthesis of DNA‐encoded disulfide‐ and thioether‐cyclized peptides

Christian Heinis, Van Manh Pham, Milan Bergeron-Brlek

DNA-encoded chemical library technologies enable the screening of large combinatorial libraries of chemically and structurally diverse molecules, including short cyclic peptides. A challenge in the combinatorial synthesis of cyclic peptides is the final st ...

2020

Hydrothermally Stable Sulfonated Carbons as Solid Acid Catalysts for the Hydrolysis of Lignocellulose

David Ferdinand Scholz

The recycling of homogeneous acids imposes great challenges to the feasibility of lignocellulose hydrolysis processes. Although heterogeneous catalysts would offer a perspective to circumvent these challenges, conventional solid acids are instable under th ...

EPFL2019

Rapid Performance Optimization Method for Photoelectrodes

Sophia Haussener, Yannick Kenneth Gaudy

We report the development of a rapid method for the performance optimization of photoelectrodes. The method requires as an input incident photon-to-current efficiency (IPCE) measurements of a material at two or more wavelengths, an estimation of the comple ...

2019

Selective synthesis of dimethyl ether on eco-friendly K10 montmorillonite clay

Jeremy Luterbacher, Oliver Kröcher, Florent Emmanuel Héroguel, Alimohammad Bahmanpour, Christophe Jean Baranowski

The methanol dehydration reaction was studied over environmentally benign, easily accessible and inexpensive K10 montmorillonite clay used as the catalyst at a temperature range between 200–700 °C. Nearly 100% selectivity towards dimethyl ether (DME) at 80 ...

2018