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Concept

Neuromyélite optique

Publications associées (20)

Multiparametric Characterization and Spatial Distribution of Different MS Lesion Phenotypes

Tobias Kober, Tom Hilbert, Gian Franco Piredda

BACKGROUND AND PURPOSE: MS lesions exhibit varying degrees of axonal and myelin damage. A comprehensive description of lesion phenotypes could contribute to an improved radiologic evaluation of smoldering inflammation and remyelination processes. This stud ...

Amer Soc Neuroradiology2024

Cortical lesions, central vein sign, and paramagnetic rim lesions in multiple sclerosis: Emerging machine learning techniques and future avenues

Jean-Philippe Thiran, Tobias Kober, Meritxell Bach Cuadra, Cristina Granziera, Francesco La Rosa

The current diagnostic criteria for multiple sclerosis (MS) lack specificity, and this may lead to misdiagnosis, which remains an issue in present-day clinical practice. In addition, conventional biomarkers only moderately correlate with MS disease progres ...

ELSEVIER SCI LTD2022

Optical phase contrast imaging of human retinal cells by changing the tissue refractive index

Christophe Moser, Timothé Laforest, Laura Emmanuelle Kowalczuk, Mathieu Künzi

Purpose : Based on oblique partially coherent illumination of transparent samples, we developed a simple custom Optical Phase Imaging (OPI) microscope providing a label-free, semi-quantitative phase contrast imaging. The aim of this study was to explore th ...

ASSOC RESEARCH VISION OPHTHALMOLOGY INC2020

CVSnet: A machine learning approach for automated central vein sign assessment in multiple sclerosis

Reto Meuli, Tobias Kober, Meritxell Bach Cuadra, Cristina Granziera, Jonas Richiardi, Francesco La Rosa, João Pedro Forjaco Jorge

The central vein sign (CVS) is an efficient imaging biomarker for multiple sclerosis (MS) diagnosis, but its application in clinical routine is limited by inter-rater variability and the expenditure of time associated with manual assessment. We describe a ...

2020

Serum GFAP in multiple sclerosis: correlation with disease type and MRI markers of disease severity

Tobias Kober, Bénédicte Marie Maréchal, Ricardo Alberto Corredor Jerez

Neurofilament light chain (NfL) has been demonstrated to correlate with multiple sclerosis disease severity as well as treatment response. Nevertheless, additional serum biomarkers are still needed to better differentiate disease activity from disease prog ...

Nature Research2020

RimNet: A deep 3D multimodal MRI architecture for paramagnetic rim lesion assessment in multiple sclerosis

Tobias Kober, Meritxell Bach Cuadra, Cristina Granziera, Francesco La Rosa

Objectives In multiple sclerosis (MS), the presence of a paramagnetic rim at the edge of non-gadolinium-enhancing lesions indicates perilesional chronic inflammation. Patients featuring a higher paramagnetic rim lesion burden tend to have more aggressive d ...

2020

An Ultra-High Field Study of Cerebellar Pathology in Early Relapsing-Remitting Multiple Sclerosis Using MP2RAGE

Tobias Kober, Meritxell Bach Cuadra, Cristina Granziera, Gunnar Krüger, Alexis Roche, Guillaume Bonnier, Kieran O'Brien, Pavel Falkovskiy

Objectives: The aim of this study was to study focal cerebellar pathology in early stages of multiple sclerosis (MS) using ultra-high-field magnetization-prepared 2 inversion-contrast rapid gradient-echo (7T MP2RAGE). Materials and Methods: Twenty early-st ...

Lippincott, Williams & Wilkins2017

Regulation Of Neuron-Astrocyte Metabolic Coupling Across The Sleep-Wake Cycle

Pierre Magistretti

Over the last thirty years, a growing number of studies showed that astrocytes play a pivotal role in the energy support to synapses. More precisely, astrocytes adjust energy production to neuronal energy needs through different mechanisms grouped under th ...

Elsevier2016

Multicontrast connectometry: A new tool to assess cerebellum alterations in early relapsing‐remitting multiple sclerosis

Jean-Philippe Thiran, Dimitri Nestor Alice Van De Ville, Alessandro Daducci, Gunnar Krüger, Djalel Eddine Meskaldji, Gloria Menegaz, Cristina Granziera, David Paul Roger Romascano, Alexis Roche, Jonas Richiardi, Ying-Chia Lin, Guillaume Bonnier

Background: Cerebellar pathology occurs in late multiple sclerosis (MS) but little is known about cerebellar changes during early disease stages. In this study, we propose a new multicontrast “connectometry” approach to assess the structural and functional ...

Wiley-Blackwell2015

Quantitative Analysis of Myelin and Axonal Remodeling in the Uninjured Motor Network After Stroke

Jean-Philippe Thiran, Reto Meuli, Alessandro Daducci, Cristina Granziera, Gunnar Krüger, Djalel Eddine Meskaldji, Gloria Menegaz

Objectives: Contralesional brain connectivity plasticity was previously reported after stroke. This study aims at disentangling the biological mechanisms underlying connectivity plasticity in the uninjured motor network after an ischemic lesion. In particu ...

2015

Clinical Proton MR Spectroscopy in Central Nervous System Disorders

Rolf Gruetter, Cristina Ramona Cudalbu Moldovan

A large body of published work shows that proton (hydrogen 1 [(1)H]) magnetic resonance (MR) spectroscopy has evolved from a research tool into a clinical neuroimaging modality. Herein, the authors present a summary of brain disorders in which MR spectrosc ...

2014

Connexin 30 sets synaptic strength by controlling astroglial synapse invasion

Graham Knott, Nicole Déglon

Astrocytes play active roles in brain physiology by dynamic interactions with neurons. Connexin 30, one of the two main astroglial gap-junction subunits, is thought to be involved in behavioral and basic cognitive processes. However, the underlying cellula ...

Nature Publishing Group2014

Connectivity and tissue microstructural alterations in right and left temporal lobe epilepsy revealed by diffusion spectrum imaging

Jean-Philippe Thiran, Alessandro Daducci, François Lazeyras, Nicolas Kunz, Alia Lemkaddem

Focal epilepsy is increasingly recognized as the result of an altered brain network, both on the structural and functional levels and the characterization of these widespread brain alterations is crucial for our understanding of the clinical manifestation ...

2014

Advanced MRI unravels the nature of tissue alterations in early multiple sclerosis

Jean-Philippe Thiran, Cristina Granziera, Gunnar Krüger, Djalel Eddine Meskaldji, Gloria Menegaz, David Paul Roger Romascano, Alexis Roche, Guillaume Bonnier, Ying-Chia Lin

In patients with multiple sclerosis (MS), conventional magnetic resonance imaging (MRI) provides only limited insights into the nature of brain damage with modest clinic-radiological correlation. In this study, we applied recent advances in MRI techniques ...

2014

An Adeno-Associated Virus-Based Intracellular Sensor of Pathological Nuclear Factor-kappa B Activation for Disease-Inducible Gene Transfer

Elias Georges Gebara

Stimulation of resident cells by NF-kappa B activating cytokines is a central element of inflammatory and degenerative disorders of the central nervous system (CNS). This disease-mediated NF-kappa B activation could be used to drive transgene expression se ...

Public Library Science2013

Whole-brain structural connectivity in temporal lobe epilepsy: a Diffusion Spectrum Imaging study

Jean-Philippe Thiran, Alessandro Daducci, Alessandra Griffa, Alia Lemkaddem, François Lazeyras

Introduction: Medial Temporal Lobe Epilepsy (mTLE) with hippocampal sclerosis is the most frequent cause of drug-resistant focal epilepsy in adults. These patients suffer from widespread subtle white matter abnormalities and abnormal functional connectivit ...

2012

A multi-center study: Intra-scan and inter-scan variability of Diffusion Spectrum Imaging

Jean-Philippe Thiran, Alessandro Daducci, Gunnar Krüger, Alia Lemkaddem, François Lazeyras, Kieran O'Brien

The objective of this study was to investigate whether it is possible to pool together diffusion spectrum imaging data from four different scanners, located at three different sites. Two of the scanners had identical configuration whereas two did not. To m ...

Elsevier2012

Altered Glycogen Metabolism in Cultured Astrocytes from Mice with Chronic Glutathione Deficit; Relevance for Neuroenergetics in Schizophrenia

Pierre Magistretti, Igor Allaman

Neurodegenerative and psychiatric disorders including Alzheimer's, Parkinson's or Huntington's diseases and schizophrenia have been associated with a deficit in glutathione (GSH). In particular, a polymorphism in the gene of glutamate cysteine ligase modul ...

Public Library of Science2011

Diffusion Spectrum Imaging after stroke shows structural changes in the contra-lateral motor network correlating with functional recovery

Jean-Philippe Thiran, Reto Meuli, Alessandro Daducci, Cristina Granziera, Gunnar Krüger, Leila Cammoun, Djalel Eddine Meskaldji, Xavier Gigandet, Leila Faiza Ben Hamida Cammoun

There is growing interest in understanding the role of the non-injured contra-lateral hemisphere in stroke recovery. In the experimental field, histological evidence has been reported that structural changes occur in the contra-lateral connectivity and cir ...

2011

GDNF secreting human neural progenitor cells protect dying motor neurons, but not their projection to muscle, in a rat model of familial ALS

Patrick Aebischer

BACKGROUND: Amyotrophic lateral sclerosis (ALS) is a fatal, progressive neurodegenerative disease characterized by rapid loss of muscle control and eventual paralysis due to the death of large motor neurons in the brain and spinal cord. Growth factors such ...

Public Library of Science2007