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Concept

Nuclear bodies

Publications associées (5)

Pde-Constrained Optimization For Nuclear Mechanics

Aleix Boquet I Pujadas

We propose an image based PDE-constrained optimisation framework to compute the dynamical quantities of a cell nucleus undergoing deformation. It allows retrieving the displacement, strain and stress at each pixel of the nuclear domain, as well as the trac ...

IEEE2022

Mitocellular communication: Shaping health and disease

Johan Auwerx, Adrienne Joëlle Laurence Mottis, Sébastien Robert Victor Herzig

Throughout the animal kingdom, mitochondria are the only organelles that retain their own genome and the transcription and translation machineries that are all essential for energy harvesting. Mitochondria have developed a complex communication network, al ...

American Association for the Advancement of Science2019

Nuclear Proteomics Uncovers Diurnal Regulatory Landscapes in Mouse Liver

Felix Naef, Frédéric Bruno Martin Gachon, Loïc Dayon, Daniel Alain Dominique Marie Mauvoisin, Jingkui Wang

Diurnal oscillations of gene expression controlled by the circadian clock and its connected feeding rhythm enable organisms to coordinate their physiologies with daily environmental cycles. While available techniques yielded crucial insights into regulatio ...

Cell Press2017

Proteins Binding to and Regulating Human Telomeric Transcripts

Katarzyna Sikora

Telomere are the protective terminal structures of linear chromosomes. The repetitive TTAGGG sequences are bound by the dedicated shelterin complex, as well as by histones carrying modifications characteristic of silent chromatin. Like the centromeric hete ...

EPFL2011

Adeno-Associated Virus Activates an Innate Immune Response in Normal Human Cells but Not in Osteosarcoma Cells

Peter Martin Beard

Adeno-associated virus (AAV) is a small, DNA-containing dependovirus with promising potential as a gene delivery vehicle. Given the variety of applications of AAV-based vectors in the treatment of genetic disorders, numerous studies have focused on the imm ...

American Society for Microbiology2011