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Riluzole is a medication used to treat amyotrophic lateral sclerosis and other motor neuron diseases. Riluzole delays the onset of ventilator-dependence or tracheostomy in some people and may increase survival by two to three months. Riluzole is available in tablet and liquid form. Riluzole was approved in the United States for the treatment of ALS by the U.S. Food and Drug Administration (FDA) in 1995. A Cochrane Library review states a 9% gain in the probability of surviving one year. Very common (>10% frequency): nausea; weakness; decreased lung function Common (1–10% frequency): headache; dizziness; drowsiness; vomiting; abdominal pain; increased aminotransferases Uncommon (0.1-1% frequency): pancreatitis; interstitial lung disease Rare (
Pierre Magistretti, Igor Allaman, Pascal Jourdain, Gabriele Grenningloh, Evelyne Ruchti, Jiangyan Yang