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Concept

Facteur de croissance épidermique

Publications associées (29)

Bacterial cell cycle dynamics: size regulation during exponential growth and role of polyphosphate during starvation response

Aster Louis K Vanhecke

Bacteria are the most diverse and abundant kingdom of life and have adapted to survive and thrive in habitats around the globe. When provided with ample nutrients they grow and divide at staggering rates, increasing their population exponentially. Upon nut ...

EPFL2019

Required growth facilitators propel axon regeneration across complete spinal cord injury

Grégoire Courtine, Mark Andrew Anderson, Nicholas David James, Cheng Wang, Sabry Leonardo Barlatey, Michael V. Sofroniew

Transected axons fail to regrow across anatomically complete spinal cord injuries (SCI) in adults. Diverse molecules can partially facilitate or attenuate axon growth during development or after injury1,2,3, but efficient reversal of this regrowth failure ...

2018

Single Live Cell Monitoring of Protein Turnover Reveals Intercellular Variability and Cell-Cycle Dependence of Degradation Rates

Felix Naef, David Michael Suter, Eric Paquet, Andrea Brigitta Alber

Cells need to reliably control their proteome composition to maintain homeostasis and regulate growth. How protein synthesis and degradation interplay to control protein expression levels remains unclear. Here, we combined a tandem fluorescent timer and pu ...

CELL PRESS2018

An essential thioredoxin is involved in the control of the cell cycle in the bacterium Caulobacter crescentus

Camille Véronique Bernadette Goemans

Thioredoxins (Trxs) are antioxidant proteins that are conserved among all species. These proteins have been extensively studied and perform reducing reactions on a broad range of substrates. Here, we identified Caulobacter crescentus Trx1 (CCNA_03653; CcTr ...

2018

Chemical composition, nutrient-balancing and biological treatment of hand washing greywater

Odile Marie Clotilde Hervás de Nalda-Larivé

On-site biological hand washing water treatment can improve global access to safe hand washing water, but requires a thorough understanding of the chemical composition of the water to be treated, and an effective treatment strategy. This study first presen ...

2018

Novel compartment-specific biosensors reveal a complementary subcellular distribution of bioactive Furin and PC7

Pierpaolo Ginefra

Proprotein Convertases (PCs) constitute a family of serine proteases that activate various hormones, growth factors and cell adhesion molecules by mediating endoproteolytic cleavage of their secreted inactive precursors during their transit in the secret ...

EPFL2018

Label-Free Quantification Proteomics for the Identification of Mesenchymal Stromal Cell Matrisome Inside 3D Poly(Ethylene Glycol) Hydrogels

Matthias Lütolf, Yannick Robert Devaud

Cells modulate the functional properties of their environment by depositing extracellular matrix (ECM) proteins during biological processes in vivo and in vitro. Despite the ECMs central role in tissue formation, its quantification in hydrogels like Matrig ...

WILEY2018

Pharmacological induction of a progenitor state for the efficient expansion of primary human hepatocytes

Didier Trono, Matthias Lütolf, Evaristo Jose Planet Letschert, Marc Samuel Friedli, Nathalie Brandenberg, Marco Cassano, Carmen Maria Unzu Ezquerro

The liver is an organ with strong regenerative capacity, yet primary hepatocytes have a low amplification potential in vitro, a major limitation for the cell-based therapy of liver disorders and for ex vivo biological screens. Induced pluripotent stem cell ...

2019

Method for preparing induced hepatic progenitor cells

Didier Trono, Marc Samuel Friedli, Carmen Maria Unzu Ezquerro

The present invention relates to a method for preparing induced hepatic progenitor cells (iHPC) comprising the steps of dedifferentiation of hepatocytes by culture with a culture medium comprising at least one activator of the Wnt signaling, Basic fibrobla ...

2017