Concept

Artificial gene synthesis

Publications associées (27)

A High-Throughput Microfluidic Platform for Mammalian Cell Transfection and Culturing

Mammalian synthetic biology could be augmented through the development of high-throughput microfluidic systems that integrate cellular transfection, culturing, and imaging. We created a microfluidic chip that cultures cells and implements 280 independent t ...

Nature Research2016

Integrating Gene Synthesis and MITOMI for Rapid Protein Engineering

Matthew Christopher Blackburn

The research described within this thesis is primarily motivated by two fields of science with reversed, yet complementary, approaches to addressing the same essential objective: manipulating and understanding the complex program of life. Whereas synthetic ...

EPFL2016

Nucleoside Analogues: Synthesis from Strained Rings

Jérôme Waser, Jérémy Vuilleumier, Sophie Lucie Racine

Nucleoside analogues are widely employed as bioactive compounds against cancer and viral infections. Consequently, it is important to develop efficient synthetic methods to access them with high efficiency and structural diversity. Herein, we present a ful ...

Wiley-V C H Verlag Gmbh2016

Genetic, structural and phenotypic properties of MS2 coliphage with resistance to ClO2 disinfection

Tamar Kohn, Anna Carratala Ripolles, Petr Leiman, Virginie Bachmann, Sergey Nazarov, Qingxia Zhong, Ricardo Cesar Guerrero Ferreira

Common water disinfectants like chlorine have been reported to select for resistant viruses, yet little attention has been devoted to characterizing disinfection resistance. Here, we investigated the resistance of MS2 coliphage to inactivation by chlorine ...

Amer Chemical Soc2016

Sensor molecules and uses thereof

Kai Johnsson, Rudolf Griss, Alberto Schena

The invention generally relates to methods, reagents and devices for determining a concentration of an analyte in a sample. Provided is a proteinaceous sensor molecule for detecting an analyte of interest (A), comprising a signal generating moiety tethered ...

2015

Facile synthesis of oligoyne amphiphiles and their rotaxanes

Holger Frauenrath, Stephen Schrettl, Tobias Hoheisel, Martin Fritzsche

Carbon-rich organic compounds containing a series of conjugated triple bonds (oligoynes) are relevant synthetic targets, but an improved access to oligoynes bearing functional groups would be desirable. Here, we report the straightforward synthesis of two ...

Royal Soc Chemistry2015

Synthetic studies towards Lundurines A-C

Michele Boghi

Recent advances in transition metal catalyzed C-H activation are revolutionizing synthetic organic chemistry, and application of this powerful synthetic tool in the context of total synthesis of complex natural products is beginning to blossom. This thesis ...

EPFL2015