Concept

Photothermal therapy

Publications associées (27)

In vitro and in vivo photocytotoxicity of boron dipyrromethene derivatives for photodynamic therapy

Hubert van den Bergh, Georges Wagnières, Patrycja Nowak-Sliwinska

To understand the effects of substitution patterns on photosensitizing the ability of boron dipyrromethene (BODIPY), two structural variations that either investigate the effectiveness of various iodinated derivatives to maximize the "heavy atom effect" or ...

American Chemical Society2010

Photodynamic Therapy Selectively Enhances Liposomal Doxorubicin Uptake in Sarcoma Tumors to Rodent Lungs

Hubert van den Bergh, Georges Wagnières, Elodie Debefve

Background: In specific conditions, photodynamic therapy (PDT) can enhance the distribution of macromolecules across the endothelial barrier in solid tumors. It was recently postulated that tumor neovessels were more responsive to PDT than the normal vascu ...

Wiley-Blackwell2010

Ruthenium Porphyrin Compounds for Photodynamic Therapy of Cancer

Paul Joseph Dyson, Wee Han Ang, Frédéric Schmitt

Five 5,10,15,20-tetra(4-pyridyl)porphyrin (TPP) areneruthenium(II) derivs., a p-cymeneosmium, a pentamethylcyclopentadienyliridium and a pentamethylcyclopentadienylrhodium analog were prepd. and characterized as potential photosensitizing chemotherapeutic ...

2008

Video monitoring of neovessel occlusion induced by photodynamic therapy with verteporfin (Visudyne(r)), in the CAM model

Hubert van den Bergh, Georges Wagnières, Elodie Debefve

The aim of the present study was to monitor photodynamic angioocclusion with verteporfin in capillaries. Details of this process were recorded under a microscope in real-time using a high-sensitivity video camera. A procedure was developed based on intrave ...

Springer Netherlands2008

Thrombosis efficacy induced by photodynamic therapy using different photosensitizers

Bernadette Pegaz-Toquet

Various human pathologies, such as cancers or, notably, exudative age-related macular degeneration (AMD), are characterized by an abnormal vascular proliferation (angiogenesis), which in the case of this type of AMD, can rapidly lead to blindness if no cou ...

EPFL2007

Combination therapy using aspirin-enhanced photodynamic selective drug delivery

Hubert van den Bergh, Elodie Debefve

In photodynamic therapy (PDT), excitation of a drug by light leads to a cascade of biochemical processes that can cause closure of blood vessels. It has been observed clinically that significant short-term leakage from the irradiated vasculature can occur ...

Elsevier2007

Preclinical comparison of mTHPC and verteporfin for intracavitary photodynamic therapy of malignant pleural mesothelioma

Georges Wagnières

Efficacy and tumour selectivity of photodynamic therapy with two clinically approved sensitizers (mTHPC, verteporfin) were assessed for focal intracavitary photodynamic therapy (PDT) in rodents with malignant pleural mesothelioma (MPM) at recommended drug- ...

Karger2006