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Concept

Endothelial progenitor cell

Publications associées (27)

Reciprocal interactions between endothelial cells and macrophages in angiogenic vascular niches

Michele De Palma, Mario Leonardo Squadrito

The ability of macrophages to promote vascular growth has been associated with the secretion and local delivery of classic proangiogenic factors (e.g., VEGF-A and proteases). More recently, a series of studies have also revealed that physical contact of ma ...

Elsevier Inc2013

Tumor angiogenesis is enforced by autocrine regulation of high-mobility group box 1

Patrycja Nowak-Sliwinska

The endothelium plays a pivotal role in the progression of solid tumors and is considered a highly relevant target for therapy. However, it emerges that current clinical angiogenesis inhibitors that act through inhibition of tumor-derived growth factors ar ...

2013

PHD2 regulates arteriogenic macrophages through TIE2 signalling

Michele De Palma, Mario Leonardo Squadrito

Occlusion of the main arterial route redirects blood flow to the collateral circulation. We previously reported that macrophages genetically modified to express low levels of prolyl hydroxylase domain protein 2 (PHD2) display an arteriogenic phenotype, whi ...

Wiley-Blackwell2013

The promotion of endothelial cell attachment and spreading using FNIII10 fused to VEGF-A(165)

Jeffrey Alan Hubbell, Melody Swartz

Synergy in the downstream signaling pathways of the vascular endothelial growth factor receptor-2 (VEGFR-2) and the integrin alpha v beta 3 is critical for blood vessel formation. Thus, agents that activate both receptors could possess efficient pro-angiog ...

Elsevier2013

Angiostatic kinase inhibitors to sustain photodynamic angio-occlusion

Hubert van den Bergh, Patrycja Nowak-Sliwinska, Andrea Brett Gasser, Blaise Lovisa

Targeted angiostatic therapy receives major attention for the treatment of cancer and exudative age-related macular degeneration (AMD). Photodynamic therapy (PDT) has been used as an effective clinical approach for these diseases. Since PDT can cause an an ...

2012

Secreted semaphorin 5A suppressed pancreatic tumour burden but increased metastasis and endothelial cell proliferation

Anguraj Sadanandam, Stephan Wullschleger

BACKGROUND: Our earlier reports demonstrated that membrane-bound semaphorin 5A (SEMA5A) is expressed in aggressive pancreatic cancer cells and tumours, and promotes tumour growth and metastasis. In this study, we examine whether (1) pancreatic cancer cells ...

Nature Publishing Group2012

Functional consequences of prolactin signaling in endothelial cells: a potential link with angiogenesis in pathophysiology?

Patrycja Nowak-Sliwinska

Prolactin is best known as the polypeptide anterior pituitary hormone, which regulates the development of the mammary gland. However, it became clear over the last decade that prolactin contributes to a broad range of pathologies, including breast cancer. ...

2012