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Concept

Implant dentaire

Publications associées (31)

Modeling, fabrication and validation of 3D neural interfaces for peripheral nerves and brain organoids

Outman Akouissi

This thesis presents an extensive exploration of neuroelectronic interfaces, focusing on microfabrication, in silico modeling, and their applications in designing and fabricating devices for neural interfacing. The research encompasses both peripheral nerv ...

EPFL2024

Revealing the complexity of ultra-soft hydrogel re-swelling inside the brain

Stéphanie Lacour, John Martin Kolinski, Outman Akouissi, Michael Shur, Olivier Didier Christian Rizzo

The brain is an ultra-soft viscoelastic matrix. Sub-kPa hydrogels match the brain's mechanical properties but are challenging to manipulate in an implantable format. We propose a simple fabrication and processing sequence, consisting of de-hydration, patte ...

2023

Integrated Electronics for Deep Implants to Remotely Monitor Hemodynamics

Mustafa Besirli

The integration of technology in the medical field has greatly improved accuracy in diagnoses, thus leading to more effective treatments. Wearable and implantable medical devices offer great potential for remote patient monitoring, particularly for heart f ...

EPFL2023

A guide to preclinical evaluation of hydrogel-based devices for treatment of cartilage lesions

Dominique Pioletti, Peyman Karami, Yanheng Guo, Theofanis Stampoultzis

The drive to develop cartilage implants for the treatment of major defects in the musculoskeletal sys-tem has resulted in a major research thrust towards developing biomaterial devices for cartilage repair. Investigational devices for the restoration of ar ...

ELSEVIER SCI LTD2023

Wearable Ultrasound Interface for Prosthetic Hand Manipulation

Xingchen Yang

Ultrasound can non-invasively detect muscle deformations, which has great potential applications in prosthetic hand control. This research developed a miniaturized ultrasound device that could be integrated into a prosthetic hand socket. This compact syste ...

SPRINGER INTERNATIONAL PUBLISHING AG2022

Simultaneous Prediction of Wrist and Hand Motions via Wearable Ultrasound Sensing for Natural Control of Hand Prostheses

Xingchen Yang

Simultaneous prediction of wrist and hand motions is essential for the natural interaction with hand prostheses. In this paper, we propose a novel multi-out Gaussian process (MOGP) model and a multi-task deep learning (MTDL) algorithm to achieve simultaneo ...

IEEE-INST ELECTRICAL ELECTRONICS ENGINEERS INC2022

A Wearable Ultrasound Interface for Prosthetic Hand Control

Xingchen Yang

Ultrasound can non-invasively detect muscle deformations and has great potential applications in prosthetic hand control. Traditional ultrasound equipment was usually too bulky to be applied in wearable scenarios. This research presented a compact ultrasou ...

IEEE-INST ELECTRICAL ELECTRONICS ENGINEERS INC2022

Overcorrected Implants for Total Shoulder Arthroplasty

Yasmine Boulanaache

Glenohumeral osteoarthritis is a degenerative shoulder joint disease, which causes the breakdown of articular cartilage and bone. People affected by this disease suffer from severe pain and eventually reduced mobility and poor life quality. This disease is ...

EPFL2021

Integration of hybrid material systems in conformable neural interfaces

Florian Dylan Fallegger

Neural interfaces are devices that are implanted into the body and interface electrically with the central (CNS) or peripheral nervous system. They are inserted surgically for short periods of time or chronically to diagnose or treat several neural disease ...

EPFL2020

Catechol Containing Polyelectrolyte Complex Nanoparticles as Local Drug Delivery System for Bortezomib at Bone Substitute Materials

Martin Guillermo Mueller, Jeremy Pak Hei Wong

The proteasome inhibitor bortezomib (BZM) is one of the most potent anti-cancer drugs in the therapy of multiple myeloma. In this study, an adhesive drug delivery system (DDS) for BZM was developed. Therefore, we extended the present DDS concept of polyele ...

2020

Stability of flexible thin-film metallization stimulation electrodes: analysis of explants after first-in-human study and improvement ofin vivoperformance

Silvestro Micera, Stanisa Raspopovic, Francesco Maria Petrini

Objective.Micro-fabricated neural interfaces based on polyimide (PI) are achieving increasing importance in translational research. The ability to produce well-defined micro-structures with properties that include chemical inertness, mechanical flexibility ...

2020

Mechanical properties and cytocompatibility of dense and porous Zn produced by laser powder bed fusion for biodegradable implant applications

Andreas Mortensen, Ludger Weber

In this work, the macrotexture of dense Zn produced by laser powder bed fusion (LPBF) was studied and the mechanical properties for different tensile bar orientations were measured. The compressive strength of LPBF Zn scaffolds with five different unit cel ...

ELSEVIER SCI LTD2020

Soft, Implantable Bioelectronic Interfaces for Translational Research

Stéphanie Lacour, Grégoire Courtine, Marco Capogrosso, Jocelyne Bloch, Sébastien Jiguet, Giuseppe Schiavone, Nicolas Vachicouras, Florian Dylan Fallegger, Ivan Furfaro, Xiaoyang Kang, Andreas Rowald, Simon Borgognon, Ismael Seanez Gonzalez, Evgenia Vladimirova Roussinova

The convergence of materials science, electronics, and biology, namely bioelectronic interfaces, leads novel and precise communication with biological tissue, particularly with the nervous system. However, the translation of lab‐based innovation toward cli ...

Wiley2020

An Overview of Serum Albumin Interactions with Biomedical Alloys

Stefano Mischler, Anna Neus Igual Muñoz, Oksana Klok

Understanding the interactions between biomedical alloys and body fluids is of importance for the successful and safe performance of implanted devices. Albumin, as the first protein that comes in contact with an implant surface, can determine the biocompat ...

2020

Decoding of grasping tasks from intraneural recordings in trans-radial amputee

Silvestro Micera, Stanisa Raspopovic, Ivo Strauss, Giacomo Valle, Francesco Maria Petrini

Objective. A major challenge in neuroprosthetics is the restoration of sensory-motor hand functions in upper-limb amputees. Neuroprostheses based on the direct re-connection of the peripheral nerves may be an interesting approach for re-establishing the na ...

2020

Rapid evaluation of bioactive Ti-based surfaces using an in vitro titration method

Paul Bowen, Jacques Lemaître, Weitian Zhao

The prediction of implant behavior in vivo by the use of easy-to-perform in vitro methods is of great interest in biomaterials research. Simulated body fluids (SBFs) have been proposed and widely used to evaluate the bone-bonding ability of implant materia ...

Springer2019

Bio-inspired design and validation of the Efficient Lockable Spring Ankle (ELSA) prosthesis

Mohamed Bouri, François André Heremans

Over the last decade, active lower-limb prostheses demonstrated their ability to restore a physiological gait for transfemoral amputees by supplying the required positive energy balance during daily life locomotion activities. However, the added-value of s ...

IEEE2019

Spatiotemporal stimulation strategies in neuroprostheses to improve locomotion after spinal cord injury

Jérôme Gandar

Spinal cord injury (SCI) disrupts communication within central nervous system and lead to range of neurological disorders including paralysis. Current rehabilitation strategies to restore locomotion are poorly effective in people with severe SCI. Epidural ...

EPFL2019

Adsorption of HPDX and CaHPOx (x=1, ...,4) molecules on anatase TiO2 (001) surfaces

Alfonso Baldereschi

perform DFT calculations within the COSMO framework to study the adsorption properties of the CaHPOx (x = 1,...,4) phosphate family, and of the related HPOx acids, on a paradigmatic anatase (001) surface. Of particular interest is CaHPO4, a precursor of hy ...

ELSEVIER SCIENCE BV2019

A methodology for characterizing the electrochemical stability of DLC coated interlayers and interfaces

Stefano Mischler, Emilija Ilic

DLC coatings are often deposited on Si and Cr based adhesion-promoting interlayers to mitigate stress at the DLC/substrate interface. Interlayers reduce the likelihood of mechanical coating delamination. However, their chemical stability at miniature DLC c ...

ELSEVIER SCIENCE SA2019