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Concept

Mathématiques computationnelles

Publications associées (27)

Targeting molecular surfaces to engineer novel protein-based immunogens and inhibitors

Sarah Wehrle

Proteins are the basic building blocks necessary for the operation and regulation of virtually all functions in living organisms. Over millions of years, evolution has created a vast repertoire of proteins finely tuned to execute their biological functions ...

EPFL2022

Spearheading future omics analyses using dyngen, a multi-modal simulator of single cells

Wouter Jozef L Saelens

We present dyngen, a multi-modal simulation engine for studying dynamic cellular processes at single-cell resolution. dyngen is more flexible than current single-cell simulation engines, and allows better method development and benchmarking, thereby stimul ...

Nature Research2021

On the exploration of novel methodological approaches for immunogen design: case studies in influenza and hepatitis C

Andreas Scheck

Proteins are fundamental components in biological systems and crucial for a variety of biological functions. Over the last decades, significant progress in structural biology has facilitated the study of proteins and their interactions with molecular partn ...

EPFL2021

A Champion for Chemistry: Elements of Jim Morgan's Intellectual Legacy

Janet Gordon Hering

James (Jim) Morgan was a leading figure in the field of environmental science and engineering. He championed the application of chemistry in the study of the environment and the design and optimization of environmental treatment processes. Jim influenced t ...

AMER CHEMICAL SOC2021

Bistable Auxetic Surface Structures

Mark Pauly, Francis Julian Panetta, Tian Chen

We present Bistable Auxetic Surface Structures, a novel deployable material system based on optimized bistable auxetic cells. Such a structure can be flat-fabricated from elastic sheet material, then deployed towards a desired double-curved target shape by ...

2021

State of the Art on Computational Design of Assemblies with Rigid Parts

Mark Pauly, Ziqi Wang, Peng Song

An assembly refers to a collection of parts joined together to achieve a specific form and/or functionality. Designing assemblies is a non-trivial task as a slight local modification on a part's geometry or its joining method could have a global impact on ...

WILEY2021

The influence of the crowding assumptions in biofilm simulations

Vassily Hatzimanikatis, Liliana Angeles Martinez

Author summary In nature, many organisms grow in crowded biofilms that protect against stressful conditions, making their control/eradication a challenge. Modeling these microbial systems is a valuable tool for studying the interactions among cells and exp ...

2021