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Concept

Childhood trauma

Publications associées (13)

Adolescent Stress-Induced Ventral Hippocampus Redox Dysregulation Underlies Behavioral Deficits and Excitatory/Inhibitory Imbalance Related to Schizophrenia

Maria del Carmen Sandi Perez, Dogukan Hazar Ülgen

Background and hypothesis: Redox dysregulation has been proposed as a convergent point of childhood trauma and the emergence of psychiatric disorders, such as schizophrenia (SCZ). A critical region particularly vulnerable to environmental insults during ad ...

2024

High levels of childhood trauma associated with changes in hippocampal functional activity and connectivity in young adults during novelty salience

Elenor Morgenroth

Childhood trauma (CT) has been linked to increased risk for psychosis. Moreover, CT has been linked to psychosis phenotypes such as impaired cognitive and sensory functions involved in the detection of novel sensory stimuli. Our objective was to investigat ...

SPRINGER HEIDELBERG2023

Genetic selection for low glucocorticoid responsiveness recapitulates PTSD-related phenotypes: a behavioral, neuroimaging and sleep-physiology study

Silvia Monari

Humans show inter-individual differences in vulnerability to develop post-traumatic stress disorder (PTSD) following exposure to trauma. Several critical biobehavioral features have been consistently described in PTSD patients, including blunted cortisol l ...

EPFL2022

Design of Digital Mediation Tool for Self-disclosing PTSD

Denis Gillet, Isabelle Barbara Marie-Hélène Cardia, Delphine Preissmann

Establishing trust is an important aspect of the design of technological tools for mental health, as individuals are persuaded to disclose personal distressing experiences when privacy is ensured. This work-in-progress paper presents an interdisciplinary r ...

2020

Chronic corticosterone aggravates behavioral and neuronal symptomatology in a mouse model of alpha-synuclein pathology

Hilal Lashuel, Maria del Carmen Sandi Perez, Johannes Burtscher, Anass Chiki, João Pedro de Matos Rodrigues, Jean-Christophe Copin

Debilitating, yet underinvestigated nonmotor symptoms related to mood/emotion, such as depression, are common in Parkinson's disease. Here, we explore the role of depression and of the amygdala, a brain region robustly linked to mood/emotion, in synucleino ...

2019

Redox dysregulation as a link between childhood trauma and psychopathological and neurocognitive profile in patients with early psychosis

Patric Hagmann, Alessandra Griffa

Exposure to childhood trauma (CT) increases the risk for psychosis and affects the development of brain structures, possibly through oxidative stress. As oxidative stress is also linked to psychosis, it may interact with CT, leading to a more severe clinic ...

National Academy of Sciences2018

Stress Impacts the Regulation Neuropeptides in the Rat Hippocampus and Prefrontal Cortex

Aurélie Lattion, Laura Lozano Montes

Adverse life experience increases the lifetime risk to several stress-related psychopathologies, such as anxiety or depressive–like symptom following stress in adulthood. However, the neurochemical modulations triggered by stress have not been fully charac ...

2018

Electroencephalogram (EEG) Frontal Asymmetry and Error-Related Signals Are Potential Markers of Internalizing and Externalizing Behaviors in Children: A Meta-Analysis

Michael Herzog, Ophélie Gladys Favrod

Objectives: The frontal hemispheric asymmetry and error-related components, as measured by EEG, are often considered to be biological correlates or “indicators of risk” for psychopathology. Here, we performed a meta-analysis to define specific patterns of ...

2017

Brain metabolic alterations in mice subjected to postnatal traumatic stress and in their offspring

João Miguel das Neves Duarte, Alberto Corcoba

Adverse environmental and social conditions early in life have a strong impact on health. They are major risk factors for mental diseases in adulthood and, in some cases, their effects can be transmitted across generations. The consequences of detrimental ...

Sage Publications Inc2017

Age-related cognitive impairments in mice with a conditional ablation of the neural cell adhesion molecule

Maria del Carmen Sandi Perez, David Genoux

Most of the mechanisms involved in neural plasticity support cognition, and aging has a considerable effect on some of these processes. The neural cell adhesion molecule (NCAM) of the immunoglobulin superfamily plays a pivotal role in structural and functi ...

Cold Spring Harbor Lab Press, Publications Dept2013

Evidence for biological roots in the transgenerational transmission of intimate partner violence

Maria del Carmen Sandi Perez, Maria Isabel Cordero Campana, Guillaume Poirier, Vandana Veenit, Basira Salehi

Intimate partner violence is a ubiquitous and devastating phenomenon for which effective interventions and a clear etiological understanding are still lacking. A major risk factor for violence perpetration is childhood exposure to violence, prompting the p ...

2012

Smaller Global and Regional Cortical Volume in Combat-Related Posttraumatic Stress Disorder

Marie Schaer

Context Two sets of findings predict smaller cerebral cortical gray matter volume in adult posttraumatic stress disorder (PTSD). Measures of intracranial tissue volume and cerebral tissue volume have been observed to be smaller in adolescents with maltreat ...

2009

Stress-induced cognitive and psychopathological alterations : functional involvement of the neural cell adhesion molecule (NCAM)

Maria del Carmen Sandi Perez

Intensive research over the past few years has provided evidence, that stress is a potent modulator of brain function and cognition. In particular cognitive and emotional processes have been shown to be susceptible to modulation by stress. Whereas acute st ...

EPFL2009