Mediaspace scheduled maintenance: Aug 25, 2026 07:00 - 12:00 AM. During this time, videos will be temporarily unavailable. Check status updates.

Recherche

Afficher tous les résultats pour

Accueil

Concept

Schmidt reaction

Science de la nature
Chimie
Réaction chimique
Réaction de réarrangement

À propos
Confidentialité
Mentions légales

Graph Chatbot

Publications associées (24)

Page 2 sur 2

Switch-peptides as folding precursors in amyloid fibrillogenesis

Richard Alan Mimna, Lydiane Jeanine Saucède, Karine Murat, Marie-Stéphanie Camus, Sonia Dos Santos, Jérémy Bérard

Intramol. O,N-acyl migration reactions were used as structural switch (S-elements) from a depsipeptide bond contg., unfolded state (Soff) to an all-amide, native states (Son). Chem. or enzymically triggered acyl migrations allowed for the controlled induct ...

2006

"Switch peptides" : conception et synthèse d'inhibiteurs ou destructeurs potentiels de fibrilles amyloïdes

Lydiane Jeanine Saucède

Despite of considerable progress in the research at the interface of Chemistry, Biology and Medicine, neurodegenerative diseases affect more and more seriously our ageing population and remain a real therapeutic challenge for researcher. Nevertheless, adva ...

EPFL2006

Anisotropic Local Motions and Location of Amide Protons in Proteins

Geoffrey Bodenhausen

A new method has been developed to obtain dynamic and structural information about peptide planes in proteins by a combination of measurements of weak short-range cross-correlation rates R(HNN/NC') that are due to concerted fluctuations of the HN-N and N-C ...

2005

Switch-peptides: controlling biological function and self-assembly of amyloid ß-derived peptides using enzyme-triggered acyl migrations

Sonia Dos Santos

Conformational transitions of peptides and proteins have recently moved to the center of interest in various domains of research at the interface of chemistry, biology, and medicine due to their implication in an increasing number of diseases in which the ...

EPFL2005