Catégorie

Neuroanatomie

Publications associées (37)

Integrated Wireless Power, Data Communication, and Thermal Sensing System for Autonomous Multisite Brain Implants

Implanted medical devices (IMDs) have been widely developed to support the monitoring and recording of biological data inside the body or brain. Wirelessly powered IMDs, a subset of implantable electronics, have been proposed to eliminate the limitations r ...

EPFL2024

Modeling, fabrication and validation of 3D neural interfaces for peripheral nerves and brain organoids

Outman Akouissi

This thesis presents an extensive exploration of neuroelectronic interfaces, focusing on microfabrication, in silico modeling, and their applications in designing and fabricating devices for neural interfacing. The research encompasses both peripheral nerv ...

EPFL2024

Large-scale in-silico analysis of CSF dynamics within the subarachnoid space of the optic nerve

Gilles Fourestey

BackgroundImpaired cerebrospinal fluid (CSF) dynamics is involved in the pathophysiology of neurodegenerative diseases of the central nervous system and the optic nerve (ON), including Alzheimer's and Parkinson's disease, as well as frontotemporal dementia ...

BMC2024

Multimodal transcriptomic atlases of mouse spinal cord injury

Matthieu Pierre Gautier

A spinal cord injury (SCI) triggers a cascade of molecular and cellular responses involving inflammatory cell infiltration and cytokine release, apoptosis, demyelination, excitotoxicity, ischemia, and the formation of a fibrotic scar surrounded by an astro ...

EPFL2024

Neurobiological and metabolic basis of motivation and effort-based decision-making - A human 1H-MRS, fMRI and machine learning study

Arthur Barakat

Motivation is a multifaceted phenomenon that we explore within the framework of decision-making. Through this cognitive process, actions are directed towards specific goals by performing a trade-off between the cost and benefit of an action. The dorsomedia ...

EPFL2024

Context-Aware Monitoring of Hand Motor Primitives in Daily Life Activities: A Pathway to Objectively Assess Rehabilitation of Patients with Upper-Limb Neurological Impairment

Yasaman Izadmehr

The hands, our silent performers in daily life, face overwhelming challenges when neurological impairments disrupt the simple tasks that compose our daily symphony. This thesis unveils a comprehensive framework for the objective monitoring of upper-limb re ...

EPFL2024

Safety, tolerability and blinding efficiency of non-invasive deep transcranial temporal interference stimulation: first experience from more than 250 sessions

Friedhelm Christoph Hummel, Maximilian Jonas Wessel, Elena Beanato, Pierre Theopistos Vassiliadis, Fabienne Windel

Objective. Selective neuromodulation of deep brain regions has for a long time only been possible through invasive approaches, because of the steep depth-focality trade-off of conventional non-invasive brain stimulation (NIBS) techniques. Approach. An appr ...

Iop Publishing Ltd2024

Parental status and markers of brain and cellular age: A 3D convolutional network and classification study

Donal Patrick Hill

Recent research shows prominent effects of pregnancy and the parenthood transition on structural brain characteristics in humans. Here, we present a comprehensive study of how parental status and number of children born/fathered links to markers of brain a ...

Pergamon-Elsevier Science Ltd2024

Machine-learning predictor of nerve fiber firing rate allows the automatic optimization of electrical stimulation protocols

Silvestro Micera, Simone Romeni, Gabriele Marino

Computational models have been widely employed to study the electrical stimulation of the nervous system. Still, most applications either study fundamental mechanisms underlying stimulation, or address qualitative scientific questions. When quantitative qu ...

IEEE2023

Brain Regional Differences in the Developing Brain Using an Animal Model of Type C Hepatic Encephalopathy

Cristina Ramona Cudalbu Moldovan, Dunja Simicic, Katarzyna Pierzchala, Stefanita-Octavian Mitrea

Lippincott Williams & Wilkins2023

Brain reactions to the use of sensorized hand prosthesis in amputees

Silvestro Micera, Ivo Strauss, Stanisa Raspopovic, Giacomo Valle, Francesco Maria Petrini, Fabrizio Vecchio, Edoardo D'Anna

Objective We investigated for the first time the presence of chronic changes in the functional organization of sensorimotor brain areas induced by prolonged training with a bidirectional hand prosthesis. Methods A multimodal neurophysiological and neuroima ...

2020

Reaching articular limits can negatively impact embodiment in virtual reality

Olaf Blanke, Ronan Boulic, Bruno Herbelin, Thibault Serge Mario Porssut

Providing Virtual Reality(VR) users with a 3D representation of their body complements the experience of immersion and presence in the virtual world with the experience of being physically located and more personally involved. A full-body avatar representa ...

2022

Complete and long-term rescue of lesioned adult motoneurons by lentiviral-mediated expression of glial cell line-derived neurotrophic factor in the facial nucleus

Patrick Aebischer, Nicole Déglon

To date, delivery of neurotrophic factors has only allowed to transiently protect axotomized facial motoneurons against cell death. In the present report, long-term protection of these neurons was evaluated by continuously expressing the neurotrophic facto ...

2000

Pansynaptic Enlargement at Adult Cortical Connections Strengthened by Experience

Graham Knott

Behavioral experience alters the strength of neuronal connections in adult neocortex. These changes in synaptic strength are thought to be central to experience-dependent plasticity, learning, and memory. However, it is not known how changes in synaptic tr ...

Oxford University Press2014

Selective Recruitment of Arm Motoneurons in Nonhuman Primates Using Epidural Electrical Stimulation of the Cervical Spinal Cord

Stéphanie Lacour, Grégoire Courtine, Marco Capogrosso, Jocelyne Bloch, Giuseppe Schiavone

Recovery of reaching and grasping ability is the priority for people with cervical spinal cord injury (SCI). Epidural electrical stimulation (EES) has shown promising results in improving motor control after SCI in various animal models and in humans. Nota ...

2018

In Silico Voltage-Sensitive Dye Imaging: A Model-Based Approach for Bridging Scales of Cortical Activity

Taylor Howard Newton

An understanding of how microscale voltage fluctuations interact to shape mesoscale cortical information processing is lacking. Voltage-sensitive dye imaging (VSDI) is a powerful technique for interrogating membrane potential dynamics in assemblies of cort ...

EPFL2019

A modular strategy for next-generation upper-limb sensory-motor neuroprostheses

Silvestro Micera, Solaiman Shokur, Giuseppe Schiavone

Neuroprosthetics is a discipline that aims at restoring lost functions to people affected by a variety of neurological disorders or neuro-traumatic lesions. It combines the expertise of computer science and electrical, mechanical, and micro/nanotechnology ...

ELSEVIER2021