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The Microbiome Adaptation to the Changing Environment (MACE) laboratory at EPFL focuses on understanding how microbial communities adapt and thrive in cryospheric environments, particularly in response to climate change and anthropogenic stressors. By integrating field studies, laboratory experiments, multi-omics techniques, and modeling, the research emphasizes population-level responses of microbial communities and individual molecular adaptation strategies of cryophilic microorganisms. The lab aims to predict and mitigate disruptions to cryospheric terrestrial ecosystems by studying microbial interactions, microbial adaptation in the cryosphere, and the ecological and climate impacts of Greenlandic glacial outwash plains.