Unit

Laboratory of Functional and Metabolic Imaging

Laboratory

Summary

The Leenaards-Jeantet Laboratory of Functional and Metabolic Imaging (LIFMET) at EPFL focuses on non-invasive measurement of metabolic processes and function, particularly in the context of biomedical problems such as neurochemistry and diabetes research. The lab develops innovative approaches, including multinuclear spin physics and metabolic modeling, to measure metabolic reactions in vivo. Research interests span from exploiting spin coupling between nuclei to investigating brain glucose transport and glycogen metabolism. Collaborations with various EPFL institutes enhance the understanding of metabolic concentrations in disease models. LIFMET is dedicated to transmitting knowledge through teaching at undergraduate and graduate levels, offering opportunities for student projects and lab rotations.

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Summary

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Related people (7)

Rolf Gruetter

Awards: 1999 Young Investigator Award Plenary Lectureship , International Society for Neurochemistry 2011 Fellow , ESMRMB 2011 Teaching Award , Section Sciences de la Vie, EPFL

Georges Wagnières

Georges Wagnières received his diploma degree (MSc) in physics from the University of Lausanne, Switzerland, in 1986. He obtained his doctorate in science (PhD) in physics (Biomedical optics) from the Swiss Federal Institute of Technology at Lausanne (EPFL) in 1992 and did a postdoctoral work in the Wellman Laboratories of Photomedicine (Harvard Medical School), Boston, USA, from 1993 to 1994. He also obtained a Master degree in Management of Technology delivered by the Ecole des Hautes Etudes Commerciales (HEC) of Lausanne University and the EPFL in 2001. Georges Wagnières manages a research group active in the fields of: - Detection of early superficial cancers by fluorescence imaging. - Characterization of early superficial cancers by high magnification narrow band imaging. - In vivo and in vitro measurement of the vascular and tissular oxygen concentration by time-resolved luminescence spectroscopy and imaging. - Preclinical and clinical study of new photosensitizers for photodynamic therapy (PDT). - Treatment of neurodegenerative conditions (Alzheimer, Parkinson's diseases) by photobiomodulation. - Preclinical and clinical photodynamic therapy of inflammatory bowel diseases and atheroscerotic plaque. - Improvement of the selective vascular extravasation of chemotherapeutic agents by PDT. - Monitoring the light dosimetry during PDT by fluorescence spectroscopy and imaging. - Monitoring laser treatments of the retina by reflectance imaging. - Light dosimetry and tissue optical spectroscopy. - Radiometry. - Development of light delivery systems for biomedical applications. Georges Wagnières is also co-founder and was chairman of one spin-off companies: - Medlight SA, founded in July 1997, which develops, produces and commercializes light distributors for photodynamic therapy. Georges Wagnières has currently authored more than 235 papers (more than 150 in international journals with review board) and is inventor of 18 patents. He supervised 12 PhD students up to now, and currently teaches biomedical optics and photomedicine in master programs and doctoral schools. In addition, he gives the course entitled "Physique Générale I" to biology first year students registered to the Biology School of the Lausanne's University. MAIN PUBLICATIONS Please visit: https://www.epfl.ch/labs/lifmet/wagnieres/publications/

Nathalie Just

Expertise OncologyMRI, fMRI, fMRS, Diffusion MRS,Animal ModelsAnimal physiologyOptogenetics, Chemogenetics Current work -Functional magnetic Resonance imaging in rats and mice -Manganese-enhanced MRI: High Resolution MR Imaging -Functional MR Spectroscopy in small animals - New contrasts for MRI and MRS Mission I am interested in all functional aspects of normal and diseased brain from neural activity to metabolism. -2011-present: EPFL-CIBM AIT Core - Responsible for MR Imaging developments and applications

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