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Chronic pain presents a tremendous personal, societal, and financial burden. Treatment options are often limited to managing symptoms as opposed to treating the causes, and the consequences of pharmacological treatments can be immensely harmful as evidence ...

A painful episode can lead to a life-long increase in an individual's experience of pain. Fearful anticipation of imminent pain could play a role in this phenomenon, but the neurobiological underpinnings are unclear because fear can both suppress and enhan ...

Chronic pain is common after burn injuries, and post-burn neuropathic pain is the most important complication that is difficult to treat. Scrambler therapy (ST) is a non-invasive modality that uses patient-specific electrocutaneous nerve stimulation and is ...

Objective. Meralgia paresthetica (MP) is a mononeuropathy of the exclusively sensory lateral femoral cutaneous nerve (LFCN) that is difficult to treat with conservative treatments. Afferents from the LFCN enter the spinal cord through the dorsal root entry ...

Glenohumeral osteoarthritis is a degenerative shoulder joint disease, which causes the breakdown of articular cartilage and bone. People affected by this disease suffer from severe pain and eventually reduced mobility and poor life quality. This disease is ...

Spinal cord stimulation (SCS) is an approved treatment for truncal and limb neuropathic pain. However, pain relief is often suboptimal and SCS efficacy may reduce over time, requiring sometimes the addition of other pain therapies, stimulator revision, or ...

Introduction Gamma Knife radiosurgery (GKR) is a minimally invasive surgical option for drug-resistant essential glossopharyngeal neuralgia (GPN). The authors reviewed pain outcomes and complications in GPN patients who underwent a second or a third GKR fo ...

Whereas impaired multisensory processing of bodily stimuli and distorted body representation are well-established in various chronic pain disorders, such research has focused on exteroceptive bodily cues and neglected bodily signals from the inside of the ...

Our brain constantly receives and integrates a flow of multisensory bodily inputs that are responsible for the way our body is represented and consciously experienced. However, in some pathological conditions, patients might experience altered perceptions ...

OBJECTIVES: To develop and test a new immersive digital technology for complex regional pain syndrome (CRPS) that combines principles from mirror therapy and immersive virtual reality and the latest research from multisensory body processing. METHODS: In t ...

Inhibitors of sepiapterin reductase and uses of sepiapterin reductase inhibitors in analgesia, treatment of acute and chronic pain, anti-inflammation, and immune cell regulation are disclosed. ...

Motor imagery (MI) allows one to mentally represent an action without necessarily performing it. Importantly, however, MI is profoundly influenced by the ability to actually execute actions, as demonstrated by the impairment of this ability as a consequenc ...

Various studies have reported alterations of spinal kinematics in patients with chronic low back pain (CLBP) during gait. However, while recent findings stressed the importance of multi-segment analysis, most of prior gait studies modelled the lumbar spine ...

Background: Chronic pain, defined as persistent or recurrent pain lasting longer than 3 months, is a frequent condition affecting an important percent of population worldwide. Pain chronicity can be caused by many different factors and is a frequent compon ...

While alterations in spinal kinematics have been frequently reported in patients with chronic low back pain (CLBP), a better characterization of the kinematics during functional activities is needed to improve our understanding and therapeutic solutions fo ...

Replacing the gel-like central part of the intervertebral disc (IVD), so-called nucleus pulposus (NP), via a minimally invasive surgery is one of the most recent approaches in the lower back pain treatments. An appropriate biomaterial for NP replacement (N ...

Intervertebral disc degeneration is a major reason why we experience low back pain. Intervertebral discs are located in-between the vertebrae of the spine. They act, among other, as shock absorbers by distributing the mechanical load applied to the spine w ...

Looking at one's own body might induce visual analgesia. However, the cognitive and physiological mechanisms underlying such visual analgesia are unknown. Because body and pain representations in the brain are multisensory, and have been reported to partia ...

Complications related to the neck-stem junction of modular stems used for total hip arthroplasty (THA) are generating increasing concern. A 74-year-old male had increasing pain and a cutaneous reaction around the scar 1 year after THA with a modular neck-s ...

Recent preclinical advances highlight the therapeutic potential of treatments aimed at boosting regeneration and plasticity of spinal circuitry damaged by spinal cord injury (SCI). With several promising candidates being considered for translation into cli ...

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A Stand-Alone Augmented Reality Intervention for Chronic Pain using Embodied Systolic Stimulation

Prefrontal engrams of long-term fear memory perpetuate pain perception

Scrambler Therapy for Chronic Pain after Burns and Its Effect on the Cerebral Pain Network: A Prospective, Double-Blinded, Randomized Controlled Trial

Targeted dorsal root entry zone stimulation alleviates pain due to meralgia paresthetica

Overcorrected Implants for Total Shoulder Arthroplasty

Enhancing analgesic spinal cord stimulation for chronic pain with personalized immersive virtual reality

The outcomes of a second and third Gamma Knife radiosurgery for recurrent essential glossopharyngeal neuralgia

Behavioral and neurophysiological evidence for altered interoceptive bodily processing in chronic pain

Cognitive neuroprosthetics for investigating and restoring body perception

Heartbeat-enhanced immersive virtual reality to treat complex regional pain syndrome

Sepiapterin reductase inhibitors

Motor imagery in spinal cord injured people is modulated by somatotopic coding, perspective taking, and post-lesional chronic pain

Chronic low back pain patients walk with locally altered spinal kinematics

Quantifying dimensions of physical behavior in chronic pain conditions

Multi-segment analysis of spinal kinematics during sit-to-stand in patients with chronic low back pain

Nano Fibrillated Cellulose Based Composite Hydrogels for an Injectable Intervertebral Disc Implant

Surgical probe and implant development for nucleus pulposus replacements

Size and Viewpoint of an Embodied Virtual Body Affect the Processing of Painful Stimuli

Adverse tissue reaction to corrosion at the neck-stem junction after modular primary total hip arthroplasty

Leveraging biomedical informatics for assessing plasticity and repair in primate spinal cord injury