Increasing soil salinity causes significant crop losses globally; therefore, understanding plant responses to salt (sodium) stress is of high importance. Plants avoid sodium toxicity through subcellular compartmentation by intricate processes involving a h ...
The emergence of immunotherapy, including immune checkpoint blockade (ICB) and the adoptive transfer of cytotoxic lymphocytes, such as CAR-T cell therapy, has revolutionized
cancer treatment. However, these therapies still face significant challenges in t ...
In the last two decades, novel and promising cell-based therapies have populated the treatment landscape for haematological tumors. However, commonly exploited T and NK cell-based therapies show limited applicability to solid tumors. This is mainly given b ...
The integrated stress response (ISR) is a central signaling network that enables eukaryotic cells to respond to a variety of different environmental stresses. Such stresses cause ribosome collisions that lead to activation of the kinase Gcn2, resulting in ...
Proceedings of the National Academy of Sciences2025
It is said that all models are wrong, but some are useful. In vitro human cell-based models are a prime example of this maxim. We asked researchers: when is your model system useful? How can it be made more useful? What are its limitations? ...
The first search for soft unclustered energy patterns (SUEPs) is performed using an integrated luminosity of 138 fb(-1) of proton-proton collision data at root s = 13 TeV, collected in 2016-2018 by the CMS detector at the LHC. Such SUEPs are predicted by h ...
