Publication

Assessment of bundle-specific axon diameter distributions using diffusion MRI tractography

Jean-Philippe Thiran
2016
Conference Papers

Abstract

The main limitation of diffusion tractography for connectivity studies is that the reconstructed tractograms are not truly quantitative. Microstructure imaging allows the estimation of more quantitative features of the neuronal tissue, such as the axon diameter distribution, but this analysis can only be performed voxelwise. Here, we extend a framework that we recently proposed for evaluating the plausibility of tractograms (COMMIT) with the aim of assessing bundle-specific axon diameter distributions as well. This possibility may have implications in connectomics, as it opens new perspectives for investigating brain connectivity at different scales.

Official source

https://infoscience.epfl.ch/entities/publication/ff6a15f1-e440-405a-ab3f-3372d762f3f9

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Jean-Philippe Thiran
2016
Conference Papers

Abstract

Official source

https://infoscience.epfl.ch/entities/publication/ff6a15f1-e440-405a-ab3f-3372d762f3f9

About this result

Related concepts (22)

Tractography

In neuroscience, tractography is a 3D modeling technique used to visually represent nerve tracts using data collected by diffusion MRI. It uses special techniques of magnetic resonance imaging (MRI) and computer-based diffusion MRI. The results are presented in two- and three-dimensional images called tractograms. In addition to the long tracts that connect the brain to the rest of the body, there are complicated neural circuits formed by short connections among different cortical and subcortical regions.

Diffusion MRI

Diffusion-weighted magnetic resonance imaging (DWI or DW-MRI) is the use of specific MRI sequences as well as software that generates images from the resulting data that uses the diffusion of water molecules to generate contrast in MR images. It allows the mapping of the diffusion process of molecules, mainly water, in biological tissues, in vivo and non-invasively. Molecular diffusion in tissues is not random, but reflects interactions with many obstacles, such as macromolecules, fibers, and membranes.

Axon

An axon (from Greek ἄξων áxōn, axis), or nerve fiber (or nerve fibre: see spelling differences), is a long, slender projection of a nerve cell, or neuron, in vertebrates, that typically conducts electrical impulses known as action potentials away from the nerve cell body. The function of the axon is to transmit information to different neurons, muscles, and glands.