Publication

Lentiviral-mediated gene transfer to model triplet repeat disorders

Patrick Aebischer, Nicole Déglon, Etienne Régulier, Diana Zala
2004
Journal Articles

Abstract

This chapter describes the potential use of viral-mediated gene transfer in the central nervous system as a new strategy in developing animal models of neurodegenerative diseases. To illustrate the approach, procedures for the production of lentiviral vectors encoding polyQ proteins are provided, as well as methods for the determination of viral titers, in vitro infection, and basic protocols for in vivo studies in rodents.

Official source

https://infoscience.epfl.ch/entities/publication/fee4b6a4-70a6-4ffb-8fc8-b8a6726f2a82

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Lentiviral-mediated gene transfer to model triplet repeat disorders

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