The interplay of conditional NCAM-knockout and chronic unpredictable stress leads to increased aggression in mice

Chat with Graph Search

Ask any question about EPFL courses, lectures, exercises, research, news, etc. or try the example questions below.

DISCLAIMER: The Graph Chatbot is not programmed to provide explicit or categorical answers to your questions. Rather, it transforms your questions into API requests that are distributed across the various IT services officially administered by EPFL. Its purpose is solely to collect and recommend relevant references to content that you can explore to help you answer your questions.

Background and hypothesis: Redox dysregulation has been proposed as a convergent point of childhood trauma and the emergence of psychiatric disorders, such as schizophrenia (SCZ). A critical region particularly vulnerable to environmental insults during ad ...

Due to the increasing demands of today's fast-paced world, mental health concerns are on the rise, which necessitates innovative approaches to provide support to those in need. Open-domain conversational agents known as chatbots, offer a unique opportunit ...

The multidimensionality of the stress response has shown the complexity of this phenomenon and therefore the impossibility of finding a unique biomarker among the physiological variables related to stress. An experimental study was designed and performed t ...

Geotechnical problems with total stress changes occurring rapidly relative to the soil consolidation time can be conveniently addressed using an effective stress-based approach. For saturated states, analytical formulations of pore-pressure coefficients ad ...

Adolescent individuals exhibit great variability in cortical dynamics and behavioral outcomes. The developing adolescent brain is highly sensitive to social experiences and environmental insults, influencing how personality traits emerge. A distinct patter ...

The ongoing war in Ukraine has profoundly impacted the Ukrainian scientific community. Numerous researchers have either emigrated or transitioned to alternate professions. For those who remain in research, the destruction of civil infrastructure and psycho ...

IntroductionOne-third of mothers rate their childbirth as traumatic. The prevalence of childbirth-related post-traumatic stress disorder (CB-PTSD) is 4.7%. Skin-to-skin contact is a protective factor against CB-PTSD. However, during a caesarean section (CS ...

Team projects are an integral part of the student learning experience. However, emotions can significantly affect student performance during team projects. Students use different emotion regulation strategies, such as surface-acting (emotive dissonance) an ...

The stress state is an important parameter in terms of both earthquake nucleation and rupture. Here, a new stimulation technique is proposed for Enhanced Geothermal Systems (EGSs), which have previously been burdened with a number of high-profile incidence ...

Background: There has been an increase in interest in emotion in engineering and science ethics education. There is also evidence that emotional content in case studies may improve students’ learning and enhance awareness, understanding, and motivation con ...

Background: Understanding why only a subset of trauma-exposed individuals develop posttraumatic stress disorder is critical for advancing clinical strategies. A few behavioral (deficits in fear extinction) and biological (blunted glucocorticoid levels, sma ...

Synaptic plasticity underlies the brain’s ability to learn and adapt. While experiments in brain slices have revealed mechanisms and protocols for the induction of plasticity between pairs of neurons, how these synaptic changes are coordinated in biologica ...

Synaptic plasticity underlies our ability to learn and adapt to the constantly changing environment. The phenomenon of synapses changing their efficacy in an activity-dependent manner is often studied in small groups of neurons in vitro or indirectly throu ...

When brittle hydrogels fail, several mechanisms conspire to alter the state of stress near the tip of a crack, and it is challenging to identify which mechanism is dominant. In the fracture of brittle solids, a sufficient far-field stress results in the co ...

Weber et al. provide evidence in support of a stress-diathesis model of functional neurological disorders. They identify trauma history in the form of emotional neglect as a psychological risk factor, and reduced hippocampus and amygdala volume as a predis ...

Background: 22q11.2 deletion syndrome (22q11DS) is a neurogenetic condition associated to a high risk for psychiatric disorders, including psychosis. Individuals with 22q11DS are thought to experience increased levels of chronic stress, which could lead to ...

Humans show inter-individual differences in vulnerability to develop post-traumatic stress disorder (PTSD) following exposure to trauma. Several critical biobehavioral features have been consistently described in PTSD patients, including blunted cortisol l ...

Individuals frequently differ in their behavioral and cognitive responses to stress. However, whether motivation is differently affected by acute stress in different individuals remains to be established. By exploiting natural variation in trait anxiety in ...

Although theories of emotion associate negative emotional symptoms with cognitive biases in information processing, they rarely specify the details. Here, we characterize cognitive biases in information processing of pleasant and unpleasant information, an ...

The research community of dialog generation has been interested in incorporating emotional information into the design of open-domain dialog systems ever since neural networks (sequence-to-sequence models in particular) were adopted for modeling dialogs. T ...

The interplay of conditional NCAM-knockout and chronic unpredictable stress leads to increased aggression in mice

Chat with Graph Search

Adolescent Stress-Induced Ventral Hippocampus Redox Dysregulation Underlies Behavioral Deficits and Excitatory/Inhibitory Imbalance Related to Schizophrenia

Empathetic Conversational Agents for Distress Support

Psychosomatic response to acute emotional stress in healthy students

Pore-pressure coefficients for unsaturated soils: generalized effective stress approach

Transcriptomic analysis reveals mitochondrial pathways associated with distinct adolescent behavioral phenotypes and stress response

The effects of war on Ukrainian research

'connEcted caesarean section': creating a virtual link between MOthers and their infanTs to ImprOve maternal childbirth experieNce - study protocol for a PILOT trial (e-motion-pilot)

Emotional labor experienced in team-projects: A comparison of engineering and hospitality students

Single-Well Pore Pressure Preconditioning for Enhanced Geothermal System Stimulation

Compassion and Engineering Students’ Moral Reasoning: The Emotional Experience of Engineering Ethics Cases

Blunted Glucocorticoid Responsiveness to Stress Causes Behavioral and Biological Alterations That Lead to Posttraumatic Stress Disorder Vulnerability

Assemblies, synapse clustering and network topology interact with plasticity to explain structure-function relationships of the cortical connectome

Principles of Network Plasticity in Neocortical Microcircuits

Crack tip kinematics reveal the process zone structure in brittle fracture

Identification of biopsychological trait markers in functional neurological disorders

Exploring associations between diurnal cortisol, stress, coping and psychopathology in adolescents and young adults with 22q11.2 deletion syndrome

Genetic selection for low glucocorticoid responsiveness recapitulates PTSD-related phenotypes: a behavioral, neuroimaging and sleep-physiology study

Opposite effects of stress on effortful motivation in high and low anxiety are mediated by CRHR1 in the VTA

Information Processing Biases: The Effects of Negative Emotional Symptoms on Sampling Pleasant and Unpleasant Information

Towards Empathetic Open-Domain Chatbots