Publication

Synthesis of antiparallel 4a-helix bundle TASP by chemoselective ligation

1994
Journal Articles

Abstract

The use of chemoselective ligation methods and orthogonal protection techniques allows access to Template-Assembled Synthetic Protein (TASP) mols. exhibiting a large variety of packing topologies. This is demonstrated for the synthesis of an antiparallel 4a-helical bundle TASP by condensing amphiphilic peptide blocks, contg. aldehyde functions at the C- or N-terminus, to a selectively addressable topol. template via oxime bond formation. The resulting antiparallel 4a-helix TASP is obtained in high yield and shows a template-induced helical conformation. [on SciFinder (R)]

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1994
Journal Articles

Abstract

Official source

Related concepts (23)

Peptide synthesis

In organic chemistry, peptide synthesis is the production of peptides, compounds where multiple amino acids are linked via amide bonds, also known as peptide bonds. Peptides are chemically synthesized by the condensation reaction of the carboxyl group of one amino acid to the amino group of another. Protecting group strategies are usually necessary to prevent undesirable side reactions with the various amino acid side chains. Chemical peptide synthesis most commonly starts at the carboxyl end of the peptide (C-terminus), and proceeds toward the amino-terminus (N-terminus).

Algebraic variety

Algebraic varieties are the central objects of study in algebraic geometry, a sub-field of mathematics. Classically, an algebraic variety is defined as the set of solutions of a system of polynomial equations over the real or complex numbers. Modern definitions generalize this concept in several different ways, while attempting to preserve the geometric intuition behind the original definition. Conventions regarding the definition of an algebraic variety differ slightly.

Abelian variety

In mathematics, particularly in algebraic geometry, complex analysis and algebraic number theory, an abelian variety is a projective algebraic variety that is also an algebraic group, i.e., has a group law that can be defined by regular functions. Abelian varieties are at the same time among the most studied objects in algebraic geometry and indispensable tools for much research on other topics in algebraic geometry and number theory. An abelian variety can be defined by equations having coefficients in any field; the variety is then said to be defined over that field.

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Synthesis of antiparallel 4a-helix bundle TASP by chemoselective ligation

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