A Multiomic Network Approach to Uncover Disease Modifying Mechanisms of Inborn Errors of Metabolism

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Destabilization of mutualistic interactions shapes the early heat stress response of the coral holobiont

Nils Rädecker

BackgroundThe stability of the symbiotic relationship between coral and their dinoflagellate algae (Symbiodiniaceae) is disrupted by ocean warming. Although the coral thermal response depends on the complex interactions between host, Symbiodiniaceae and pr ...

BMC2025

Gene expression flux analysis reveals specific regulatory modalities of gene expression

David Michael Suter, Benjamin Joao Clément Antonin Hadrien Martin

The level of a given protein is determined by the synthesis and degradation rates of its mRNA and protein. While several studies have quantified the contribution of different gene expression steps in regulating protein levels, these are limited by using eq ...

2023

From Genes to Organisms : Bioinformatics System Models and Software

Thomas Schaffter

The expression of genes is controlled by regulatory networks, which performspecific functions in a cell. Gene networks play a crucial role in the development of multicellular organisms by precisely coordinating spatial and temporal gene expression patterns ...

EPFL2014

Inferences of Demography and Selection in an African Population of Drosophila melanogaster

Jeffrey David Jensen

It remains a central problem in population genetics to infer the past action of natural selection, and these inferences pose a challenge because demographic events will also substantially affect patterns of polymorphism and divergence. Thus it is imperativ ...

Genetics Society of America2013