Publication

Automatic spinal cord segmentation: Generalization across MR parameters, sites, vendors and pathologies

2024

Abstract

Motivation: Spinal cord cross-sectional area (CSA) is an important biomarker for neurodegenerative and traumatic diseases. However, CSA measurements vary across MRI contrasts and imaging protocols, limiting its use in multi-center studies. Goal(s): The goal is to evaluate CSA variability using a novel contrast-agnostic segmentation method. Approach: We compared this method to the Spinal Cord Toolbox's DeepSeg, analyzing CSA across different sites, and MRI vendors. Additionally, we compared the segmentations in diverse datasets and pathologies. Results: The contrast-agnostic segmentation showed lower CSA variability, and superior performance in most cases, except for intramedullary cord compression, where the Spinal Cord Toolbox's DeepSeg was more accurate. Impact: The contrast-agnostic method yields reliable spinal cord CSA measurements, independent of MRI contrasts and vendors. This, combined with a soft segmentation output, can potentially detect subtle spinal cord atrophy in prospective multi-center cohorts.

Official source

https://infoscience.epfl.ch/entities/publication/fc019492-a902-43aa-ac4b-cbb050596431

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2024

Abstract

Official source

https://infoscience.epfl.ch/entities/publication/fc019492-a902-43aa-ac4b-cbb050596431

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Related concepts (10)

Magnetic resonance imaging

Magnetic resonance imaging (MRI) is a medical imaging technique used in radiology to form pictures of the anatomy and the physiological processes of the body. MRI scanners use strong magnetic fields, magnetic field gradients, and radio waves to generate images of the organs in the body. MRI does not involve X-rays or the use of ionizing radiation, which distinguishes it from computed tomography (CT) and positron emission tomography (PET) scans.

Medical imaging

Medical imaging is the technique and process of imaging the interior of a body for clinical analysis and medical intervention, as well as visual representation of the function of some organs or tissues (physiology). Medical imaging seeks to reveal internal structures hidden by the skin and bones, as well as to diagnose and treat disease. Medical imaging also establishes a database of normal anatomy and physiology to make it possible to identify abnormalities.

Contrast agent

A contrast agent (or contrast medium) is a substance used to increase the contrast of structures or fluids within the body in medical imaging. Contrast agents absorb or alter external electromagnetism or ultrasound, which is different from radiopharmaceuticals, which emit radiation themselves. In x-ray imaging, contrast agents enhance the radiodensity in a target tissue or structure. In magnetic resonance imaging, contrast agents shorten (or in some instances increase) the relaxation times of nuclei within body tissues in order to alter the contrast in the image.

Related publications (1)

Automatic spinal cord segmentation: Generalization across MR parameters, sites, vendors and pathologies

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