Publication

The dual role of functional pseudo-prolines for the design of novel SH3 ligands

2001
Conference Papers

Abstract

Pseudo-proline building blocks exert a dual functionality in enhancing and stabilizing the relevant polyproline II (PPII) conformation and increasing and optimizing van der Waals contacts and hydrogen bonding to the receptor mols. thus modifying affinity and specificity. They are highly useful in studying ligand recognition mediated by Src homol. 3 domains essential in cellular regulation and protein-protein interactions. The 2-C substituents promote the induction of the required PPII helix and allow for optimal complementation of the SH3 topog. [on SciFinder (R)]

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2001
Conference Papers

Abstract

Official source

Related concepts (31)

Dual system

In mathematics, a dual system, dual pair, or duality over a field is a triple consisting of two vector spaces and over and a non-degenerate bilinear map . Duality theory, the study of dual systems, is part of functional analysis. It is separate and distinct to Dual-system Theory in psychology. Pairings A or pair over a field is a triple which may also be denoted by consisting of two vector spaces and over (which this article assumes is the field either of real numbers or the complex numbers ).

Protein–protein interaction

Protein–protein interactions (PPIs) are physical contacts of high specificity established between two or more protein molecules as a result of biochemical events steered by interactions that include electrostatic forces, hydrogen bonding and the hydrophobic effect. Many are physical contacts with molecular associations between chains that occur in a cell or in a living organism in a specific biomolecular context. Proteins rarely act alone as their functions tend to be regulated.

Strong dual space

In functional analysis and related areas of mathematics, the strong dual space of a topological vector space (TVS) is the continuous dual space of equipped with the strong (dual) topology or the topology of uniform convergence on bounded subsets of where this topology is denoted by or The coarsest polar topology is called weak topology. The strong dual space plays such an important role in modern functional analysis, that the continuous dual space is usually assumed to have the strong dual topology unless indicated otherwise.