Publication

Microsurgery-aided in-situ force probing reveals extensibility and viscoelastic properties of individual stress fibers

Jean-Jacques Meister, Alexander Verkhovskiy, Chiara Gabella, Benoît Vianay, Céline Jeanne Labouesse
2016
Journal Articles

Abstract

Actin-myosin filament bundles (stress fibers) are critical for tension generation and cell shape, but their mechanical properties are difficult to access. Here we propose a novel approach to probe individual peripheral stress fibers in living cells through a microsurgically generated opening in the cytoplasm. By applying large deformations with a soft cantilever we were able to fully characterize the mechanical response of the fibers and evaluate their tension, extensibility, elastic and viscous properties.

Official source

https://infoscience.epfl.ch/entities/publication/f946b997-6da9-4dff-b1a7-691ca5d4b039

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Microsurgery-aided in-situ force probing reveals extensibility and viscoelastic properties of individual stress fibers

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