Publication

Direct Observation of Self-Assembled Monolayers, Ion Complexation, and Protein Conformation at the Gold/Water Interface: An FTIR Spectroscopic Approach

Horst Arthur Vogel
1997
Journal Articles

Abstract

A simple approach to the in situ measurement of IR spectra of self-assembled monolayers (SAMs) on gold in an aq. environment is described. A thin gold film (3-5 nm) on the surface of a germanium internal reflection element is used as a substrate for the self-assembly of a monolayer of a chelating thioalkane. High signal-to-noise spectra are obtained, allowing identification of the chem. groups present in the SAM. Complexation of ions by the SAM can be monitored, and the secondary conformation of His-tagged proteins bound to the SAM can be obsd. [on SciFinder (R)]

Official source

https://infoscience.epfl.ch/entities/publication/f90718bd-60c0-4ccf-90ca-f834eec1f997

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Horst Arthur Vogel
1997
Journal Articles

Abstract

Official source

https://infoscience.epfl.ch/entities/publication/f90718bd-60c0-4ccf-90ca-f834eec1f997

About this result

Related concepts (32)

Protein structure

Protein structure is the three-dimensional arrangement of atoms in an amino acid-chain molecule. Proteins are polymers - specifically polypeptides - formed from sequences of amino acids, which are the monomers of the polymer. A single amino acid monomer may also be called a residue, which indicates a repeating unit of a polymer. Proteins form by amino acids undergoing condensation reactions, in which the amino acids lose one water molecule per reaction in order to attach to one another with a peptide bond.

Self-assembly

Self-assembly is a process in which a disordered system of pre-existing components forms an organized structure or pattern as a consequence of specific, local interactions among the components themselves, without external direction. When the constitutive components are molecules, the process is termed molecular self-assembly. Self-assembly can be classified as either static or dynamic. In static self-assembly, the ordered state forms as a system approaches equilibrium, reducing its free energy.

Molecular self-assembly

In chemistry and materials science, molecular self-assembly is the process by which molecules adopt a defined arrangement without guidance or management from an outside source. There are two types of self-assembly: intermolecular and intramolecular. Commonly, the term molecular self-assembly refers to the former, while the latter is more commonly called folding. Molecular self-assembly is a key concept in supramolecular chemistry. This is because assembly of molecules in such systems is directed through non-covalent interactions (e.

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Direct Observation of Self-Assembled Monolayers, Ion Complexation, and Protein Conformation at the Gold/Water Interface: An FTIR Spectroscopic Approach

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