Publication

Sliding-Window Dynamic Functional Connectivity Of Resting-State Spinal Cord fMRI Reveals Specific Interaction Patterns

2023

Abstract

In recent years, while the exploration of spontaneous brain activity has shifted from static methods (i.e., examining average connectivity patterns over the entire run) towards dynamic approaches (i.e., accounting for the non-stationarity of resting-state fluctuations), the non-stationary nature of intrinsic activity in the spinal cord has seldom been studied. Here, we propose to probe time-varying functional connectivity patterns in the spinal cord using a sliding-window correlation approach, as commonly employed in the brain. Our results suggest the potential of this approach to unravel ventral-ventral and dorsal-dorsal correlation patterns, while also emphasizing their time-varying nature.

Official source

https://infoscience.epfl.ch/entities/publication/f829d5a0-def6-4db5-b7f6-fec89584c5f4

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2023

Abstract

Official source

https://infoscience.epfl.ch/entities/publication/f829d5a0-def6-4db5-b7f6-fec89584c5f4

About this result

Related concepts (32)

Brain connectivity estimators

Brain connectivity estimators represent patterns of links in the brain. Connectivity can be considered at different levels of the brain's organisation: from neurons, to neural assemblies and brain structures. Brain connectivity involves different concepts such as: neuroanatomical or structural connectivity (pattern of anatomical links), functional connectivity (usually understood as statistical dependencies) and effective connectivity (referring to causal interactions).

Spinal cord injury

A spinal cord injury (SCI) is damage to the spinal cord that causes temporary or permanent changes in its function. Symptoms may include loss of muscle function, sensation, or autonomic function in the parts of the body served by the spinal cord below the level of the injury. Injury can occur at any level of the spinal cord and can be complete, with a total loss of sensation and muscle function at lower sacral segments, or incomplete, meaning some nervous signals are able to travel past the injured area of the cord up to the Sacral S4-5 spinal cord segments.

Spinal cord

The spinal cord is a long, thin, tubular structure made up of nervous tissue, which extends from the medulla oblongata in the brainstem to the lumbar region of the vertebral column (backbone). The backbone encloses the central canal of the spinal cord, which contains cerebrospinal fluid. The brain and spinal cord together make up the central nervous system (CNS). In humans, the spinal cord begins at the occipital bone, passing through the foramen magnum and then enters the spinal canal at the beginning of the cervical vertebrae.

Related publications (1)

Sliding-Window Dynamic Functional Connectivity Of Resting-State Spinal Cord fMRI Reveals Specific Interaction Patterns

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